摘要
叶酸缺乏与胎儿脊柱裂、先天性心脏病等出生缺陷的发生有关,而母孕期通过增补叶酸可有效预防各类出生缺陷的发生,但叶酸补充过量又可能增加某些疾病的患病风险。该文将从叶酸缺乏的原因、叶酸代谢相关酶基因的单核苷酸多态性、叶酸缺乏引起出生缺陷的相关机制以及正确增补叶酸预防出生缺陷等方面进行综述。
Folic acid deficiency is associated with birth defects such as fetal spina bifida and congenital heart disease.Folic acid supplementation during pregnancy can prevent various birth defects, but excessive folic acid may increase the risk of certain diseases.This article reviews the causes of folate deficiency, single nucleotide polymorphisms of folate metabolism-related enzyme genes, the mechanism of birth defects caused by folic acid deficiency, and the correct supplementation of folic acid to prevent birth defects.
作者
李芳(综述)
王莉莉(审校)
Li Fang;Wang Lili(Medical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China)
出处
《国际儿科学杂志》
2019年第9期640-643,共4页
International Journal of Pediatrics
基金
国家自然科学基金(81971459、81471466)
辽宁省自然科学基金(2019-MS-361).
关键词
叶酸缺乏
出生缺陷
单核苷酸多态性
同型半胱氨酸
Folic acid deficiency
Birth defect
Single nucleotide polymorphism
Homocysteine
