摘要
股骨头坏死作为一种骨科常见疾病,拥有极高的致残率,且其发病逐年呈年轻化趋势,严重影响患者的生活质量。因此,早期防治股骨头坏死显得格外重要。外泌体是由细胞分泌的直径约30-100nm的囊泡状物,内含脂质、蛋白及核酸等,能调节局部微环境,促进组织损伤修复。本文就外泌体的形成、分泌以及不同来源外泌体在早期股骨头坏死防治的研究进展作一综述。
As a common disease in orthopedic field, osteonecrosis of the femoral head(ONFH) has a very high disability rate, which significantly affects the life quality of patients. Therefore, early prevention and treatment of ONFH is particularly important. Exosomes are vesicles secreted by cells, containing lipids, proteins and nucleic acids. Their diameters are about 30-100 nm in general. Accumulated evidences show that exosomes play important roles on the regulation of local microenvironment that facilitate tissue repair. The present review mainly focused on the general biological characteristics of exosomes and the present research progress of exosomes derived from different cells in the early prevention and treatment of ONFH.
作者
舒鹏
程耀锋
毛瑞琪
文涔锦
孙登龙
席姣娅
叶树楠
SHU Peng;CHENG Yao-feng;MAO Rui-qi;WEN Cen-jin;SUN Deng-long;XI Jiao-ya;YE Shu-nan(Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Physiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2019年第20期1891-1895,共5页
Orthopedic Journal of China
基金
国家自然科学基金项目（编号：81472083）
湖北省自然科学基金项目（编号：2018CFB460）
华中科技大学自主创新研究基金项目（编号：2017KFYXJJ058）
关键词
外泌体
股骨头坏死
干细胞
治疗
exosomes
osteonecrosis of the femoral head
stem cell
therapy
