摘要
目的探讨健脾利水汤配合饮食干预在体外受精-胚胎移植(IVF-ET)术后所致卵巢过度刺激综合征(OHSS)中应用效果。方法选取2015年8月至2017年8月十堰市人民医院(湖北医药学院附属十堰市人民医院)诊治的69例IVF-ET术后所致OHSS患者作为研究对象。按照随机数字表法分组,对照组(34例)采用羟乙基淀粉治疗并配合常规护理干预,观察组(35例)在对照组治疗方法的基础上加用健脾利水汤治疗并配合饮食干预。观察比较两组干预效果及干预前后红细胞比容(HCT)、纤维蛋白原(FIB)、血清学各指标[白细胞介素-6(IL-6)、血管内皮生长因子(VEGF)]水平变化情况,并统计两组妊娠率及继续妊娠率。结果观察组干预总有效率91.43%,高于对照组70.59%,差异具有统计学意义(P<0.05);干预后观察组HCT及FIB水平低于对照组,差异具有统计学意义(P<0.05);观察组干预后血清VEGF及IL-6水平低于对照组,差异具有统计学意义(P<0.05);观察组妊娠率91.43%继续妊娠率93.75%高于对照组,差异具有统计学意义64.71%、63.64%(P<0.05)。结论健脾利水汤联合饮食干预可改善IVF-ET术后OHSS患者HCT、FIB水平,下调血清IL-6、VEGF水平,提高妊娠率及继续妊娠率,效果确切。
Objective To explore the application effect of Jianpi Lishui decoction combined with dietary intervention in ovarian hyperstimulation syndrome(OHSS) after in vitro fertilization and embryo transfer(IVF-ET). Methods 69 patients with OHSS after IVF-ET in our hospital were selected and divided into two groups according to the random number table method. 34 cases in the control group were treated with hydroxyethyl starch and routine nursing intervention. 35 cases in the observation group were treated with Jianpi Lishui decoction combined with dietary intervention on the basis of the control group. The effect of intervention, changes in the levels of hematocrit(HCT), fibrinogen(FIB), and serological indicators [interleukin-6(IL-6), vascular endothelial growth factor(VEGF)] before and after intervention in the two groups were compared. The pregnancy rate and ongoing pregnancy rate in the two groups were statistically compared. Results The total effective rate in the observation group(91.43%) was higher than that of the control group(70.59%), with statistically significant difference(P<0.05). After intervention, the levels of HCT and FIB in the observation group were lower than those in the control group, with statistically significant difference(P<0.05). After intervention, the levels of serum VEGF and IL-6 in the observation group were lower than those in the control group, with statistically significant difference(P<0.05). The pregnancy rate and the ongoing pregnancy rate in the observation group was 91.43% and 93.75%, higher than the control group of 64.71% and 63.64% accordingly, with statistically signifant differences(P<0.05). Conclusions Jianpi Lishui decoction combined with dietary intervention can improve the levels of HCT and FIB in OHSS patients after IVF-ET, reduce the levels of serum IL-6 and VEGF, and increase pregnancy rate and ongoing pregnancy rate, with exact effect.
作者
陈娟
程雁
柯冉
付琴
张昌军
CHEN Juan;CHENG Yan;KE Ran;FU Qin;ZHANG ChangJun(Reproductive Medicine Center, Shiyan Municipal People′s Hospital (Shiyan People′s Hospital Affiliated to Hubei Medical College), Shiyan 442000, Hubei, China)
出处
《中国性科学》
2019年第10期94-97,共4页
Chinese Journal of Human Sexuality
关键词
卵巢过度刺激综合征
IVF-ET术
健脾利水汤
饮食干预
妊娠结局
Ovarian hyperstimulation syndrome(OHSS)
In vitro fertilization and embryo transfer(IVF-ET)
Jianpi Lishui decoction
Dietary intervention
Pregnancy outcome
