摘要
目的探讨去氧孕烯炔雌醇对围绝经功血患者雌二醇(E2)、促卵泡激素(FSH)及黄体生成素(LH)的影响。方法选取广州市妇女儿童医疗中心2015年2月~2016年4月接诊符合标准的围绝经期功血女性病例90例,按随机数字表法分为对照组和研究组,每组各45例,对照组予以米司非酮治疗;研究组予以去氧孕烯炔雌醇片治疗,两组共治疗3个月为一疗程,取肘静脉血测血清性激素、凝血机制以及血红蛋白,多普勒超声测定子宫内膜厚度、子宫动脉血流PSV、RI及PI值,同时对比临床疗效及不良反应状况。结果与治疗前比较,两组治疗后临床症状评分、经间期出血量降低,子宫内膜厚度、RI降低(P<0.05),血清FSH、LH、E2含量降低(P<0.05),APTT、PT含量降低,血红蛋白含量升高(P<0.05);与对照组比较,研究组治疗后临床症状评分、经间期出血量较低,子宫内膜厚度、RI较低,血清FSH、LH、E2含量较低,APTT、PT含量较低,血红蛋白含量较高(P<0.05);对照组有效率低于研究组(P<0.05)。结论去氧孕烯炔雌醇治疗围绝经功血效果确切,能降低激素水平及内膜厚度,提高凝血功能。
Objective To investigate the effects of desogestrel ethinyl estradiol on estradiol, follicle-stimulating hormone and luteinizing hormone in peri-menopausal women with dysfunctional uterine bleeding. Methods 40 women with peri-menopausal dysfunctional uterine bleeding were randomly divided into control group(45 cases)and study group(45 cases). The control group received Metformin(25 mg/d), and the study group received desogestrel ethinyl estradiol tablets(30 ug, bid). The serum levels of sex hormones, blood coagulation and hemoglobin were detected. Doppler ultrasonography were used to measure endometrial thickness, levels of PSV, RI and PI of uterine arterial blood flow. The clinical curative effect and adverse reaction were compared. Results Compared with before treatment, the clinical symptom score and interhemorrhage volume in 2 groups decreased after treatment, levels of endometrial thickness and RI decreased, levels of serum FSH, LH, E2 content decreased, levels of APTT, PT content decreased, and levels of Hemoglobin content increased(P<0.05). Compared with the control group, the clinical symptom score and interhemorrhage volume in study group were lower, levels of Endometrial thickness and RI were lower, levels of serum FSH, LH, E2 content were lower, and levels of APTT, PT content were lower, and levels of hemoglobin content were higher(P<0.05). The effective rate of the control group 71.11% was lower than the study group 88.89%(P<0.05). Conclusion Desogestrel with ethinyl estradiol is effective in treating perimenopausal women with dysfunctional uterine bleeding. It can decrease the levels of hormones and intima thickness and improve the coagulation function.
作者
温灿良
黄丹萍
陈鹏
谢霞
姚书忠
WEN Canliang;HUANG Danping;CHEN Peng;XIE Xia;YAO Shuzhong(Guangzhou Women's and Children's Medical Center,Guangzhou 510623 ,China;Maternal and Child Health Care Hospital of Huadu District,Guangzhou 510800 ,China;The Affiliated Hospital of Sun Yat-sen University ,Guangzhou 510080,CAzna)
出处
《西部医学》
2019年第10期1597-1600,1604,共5页
Medical Journal of West China
关键词
去氧孕烯炔雌醇
围绝经功血
雌二醇
促卵泡激素
黄体生成素
Desogestrel ethinyl estradiol
Perimenopausal dysfunctional uterine bleeding
Estradiol
Follicle stimulating hormone
Luteinizing hormone
