摘要
目的:探讨内镜下两种手术方法对消化道神经内分泌肿瘤的切除效果和安全性。方法:选取64例消化道神经内分泌肿瘤患者,随机分为A组和B组,每组各32例。A组接受内镜下黏膜切除术,B组接受内镜下黏膜剥离术。分析和比较两组所切除组织的病理学检查结果、手术时间、切除肿瘤的直径和厚度、治疗费用、住院时间、肿瘤完全切除率、垂直切缘阴性率以及并发症的发生率。结果:A组的手术时间为(8.95±1.63) min,治疗费用为(2127.70±468.31)元,均显著少于B组(P<0.05);两组患者切除肿瘤直径和厚度、住院时间、垂直切缘阴性率对比差异均没有统计学意义(P>0.05);B组的肿瘤完全切除率为93.75%,显著高于A组(P<0.05);A组并发症发生率为3.13%,显著低于B组(P<0.05)。结论:两种内镜下手术方式均可有效清除消化道神经内分泌肿瘤病灶。内镜下黏膜切除术的手术时间、费用及并发症的发生率更少低,而内镜下黏膜剥离术能够更彻底地清除肿瘤组织。
Objective: To evaluate the efficacy and safety of two kinds of endoscopic surgery for the digestive tract neuroendocrine tumors. Methods: 64 cases of patients with digestive tract neuroendocrine tumors were randomly divided into group A and group B, with 32 cases in each group. Group A received endoscopic mucosal resection and group B underwent endoscopic submucosal dissection. The pathological examination results of excised tissue were analyzed. The operation time, diameter and thickness of the tumor, cost of treatment, time of hospitalization, complete resection rate of the tumor, the negative rate of vertical margin, and the incidence of complications were compared between the two groups. Results: The operation time of group A was(8.95 ± 1.63) min, and the cost of treatment was(2127.70 ± 468.31) yuan, which were significantly lower than those of group B(P <0.05). There was no significant difference in the diameter and thickness of the tumor, time of hospitalization and negative rate of vertical margin between the two groups(P>0.05). The complete resection rate in group B was 93.75%, which was significantly higher than that in group A(P<0.05).The incidence of complications in group A was 3.13%, which was significantly lower than that in group B(P<0.05). Conclusion: Both endoscopic surgery can effectively remove the digestive tract neuroendocrine tumors. Endoscopic mucosal resection has lower operative time, cost and incidence of complications. Endoscopic submucosal dissection can remove the tumor tissue more thoroughly.
作者
唐旖旎
潘亚敏
薛仕贵
冯卓
潘骥
TANG Yi-ni;PAN Ya-min;XUE Shi-gui;FENG Zhuo;PAN Ji(Endoscopy center,Shuguang Hospital affiliated to Shanghai University of traditional Chinese Medicine,Shanghai,201203,China)
出处
《现代生物医学进展》
CAS
2019年第18期3470-3473,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金面上项目（81774079）
关键词
内镜下黏膜切除术
内镜下黏膜剥离术
消化道神经内分泌肿瘤
Endoscopic mucosal resection
Endoscopic submucosal dissection
Gastrointestinal neuroendocrine tumors
