摘要
目的:探讨甲泼尼龙联合普米克令舒治疗小儿急性喉炎的疗效及对血清干扰素-γ(IFN-γ)、淀粉样蛋白(SAA)、白介素-6(IL-6)水平的影响。方法:选择2015年6月至2018年6月我院接诊的急性喉炎患儿76例,通过随机数表法将其分为观察组40例和对照组36例。在常规治疗上,对照组以地塞米松联合普米克令舒治疗,观察组以甲泼尼龙联合普米克令舒治疗,两组均连续治疗3~5d。比较两组的临床疗效、临床症状缓解时间、治疗前后血清IFN-γ、SAA、IL-6水平的变化及不良反应的发生情况。结果:治疗后,观察组临床疗效总有效率明显高于对照组[92.50%(37/40) vs. 75.00%(27/36)](P<0.05);观察组咳嗽、声嘶、呼吸困难、哮鸣音、发热缓解时间均明显短于对照组[(3.19±0.51)d vs.(4.01±0.64)d,(1.76±0.21)d vs.(2.48±0.30)d,(1.02±0.14)d vs.(1.76±0.19)d,(2.74±0.42)d vs.(3.39±0.53)d,(1.45±0.20)d vs.(2.04±0.27)d](P<0.05);观察组血清IFN-γ、SAA、IL-6均明显低于对照组[(43.03±3.47)ng/L vs.(52.81±4.60)ng/L,(37.40±4.12)mg/L vs.(49.83±5.47)mg/L,(11.02±1.42)ng/L vs.(15.73±1.70)ng/L](P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:甲泼尼龙联合普米克令舒治疗急性喉炎患儿的临床效果显著优于地塞米松治疗,其可更有效促进疾病恢复,其内在机制可能和显著降低血清IFN-γ、SAA、IL-6水平,抑制机体过度炎症反应相关。
Objective: To study the curative efficacy of methylprednisolone combined with pulmicort in the treatment of acute laryngitis and its effect on the serum interferon-γ(IFN-γ), amyloid protein(SAA) and interleukin-6(IL-6) levels. Methods: 76 cases of patients with acute laryngitis who were treated from June 2015 to June 2018 in our hospital were selected as the research objects, they were divided into the observation group(40 cases) and the control group(36 cases) by the random number table method. On the basis of routine treatment, the control group was treated by dexamethasone combined with Pulmicort, the observation group was treated by methylprednisolone combined with Pulmicort, they were continuously treated for 3~5 d. The clinical efficacy, remission time of clinical symptoms, changes of serum IFN-γ, SAA, IL-6 levels before and after treatment and the incidence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group [92.50%(37/40) vs. 75.00%(27/36)](P <0.05);the cough, hoarseness, dyspnea, wheezing and fever remission time in the observation group were significantly shorter than those in the control group[(3.19±0.51)d vs.(4.01±0.64)d,(1.76±0.21)d vs.(2.48±0.30)d,(1.02±0.14)d vs.(1.76±0.19)d,(2.74±0.42)d vs.(3.39±0.53)d,(1.45±0.20)d vs.(2.04±0.27)d](P<0.05);the serum IFN-γ, SAA, IL-6 in the observation group were significantly lower than those in the control group[(43.03±3.47)ng/L vs.(52.81±4.60)ng/L,(37.40±4.12)mg/L vs.(49.83±5.47)mg/L,(11.02±1.42)ng/L vs.(15.73±1.70)ng/L](P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P >0.05). Conclusion: The clinical effect of methylprednisolone combined with Pulmicort resuscitation in the treatment of acute laryngitis is significantly better than that of dexamethasone alone, its internal mechanism may be related to the significant reduce of serum IFN-γ, SAA, IL-6 levels and inhibition of the excessive inflammatory response.
作者
詹文娟
唐庆
李明月
李少宁
邹宗毅
陈镜
ZHAN Wen-juan;TANG Qing;LI Ming-yue;LI Shao-ning;ZOU Zong-yi;CHEN Jing(Emergency department,Children's Hospital Affiliated to Xi'an Jiao Tong University,Xi'an children's Hospital,Xi'an,Shaanxi,710003,China)
出处
《现代生物医学进展》
CAS
2019年第18期3503-3506,共4页
Progress in Modern Biomedicine
基金
陕西省科学技术研究发展计划项目（2008K1202）
