摘要
本研究以治疗儿童哮喘类病症为研究对象,通过临床实验研究了γ-干扰素在该类疾病的临床疗效及对炎症因子的影响,具体方法是将106例哮喘患儿随机分入测试组与普通治疗组,测试组:将IFN-γ雾化后吸入进行治疗;普通治疗组:采用目前常规的治疗方法,即口服孟鲁司特,比较两组患儿治疗疗效、血清炎症因子的改变及MUC5ac蛋白水平。结果表明,两组治疗方法都能降低哮喘患儿血清炎症因子及MUC5ac水平,治疗2个月后血清炎症因子都趋于正常水平,但MUC5ac蛋白水平却呈现出差异,其中测试组能恢复到正常水平,而普通治疗组MUC5ac蛋白仍比正常值高20%。测试组诊治后治疗率为94.34%,普通治疗组疗效率为81.13%。本研究的初步结果表明,将IFN-γ雾化吸入治疗法具有更好的治疗效果,治疗周期更短。
The objective of this study was to study the treatment of children with asthma, through clinical trials, the clinical efficacy and the effect of gamma interferon on these diseases were studied. The specific method was to randomly divide 106 asthmatic children into the test group and the normal treatment group. The test group was to treat the IFN-γ with the inhalation after atomization, and the normal treatment group was to treat the conventional treatment methods, namely oral MLST, and then the treatment curative effect in two groups of children was compared in the change of serum inflammatory cytokines and MUC5ac protein levels. It was found that both set of therapeutic methods could reduce that serum inflammatory factor and MUC5ac level in asthmatic children, and that the level of the serum inflammatory factor after 2 months was normal, but the level of MUC5ac protein was different, and the test group could return to normal level, whereas the common treatment group of MUC5ac protein still 20% higher than that of the normal group. The test group makes a diagnosis and gives treatment after treatment was 94.34%, the normal treatment group efficacy rate was 81.13%. Results showed that the IFN-γ atomization inhalation therapy has a better therapeutic effect, and shorter treatment cycle.
作者
张平英
姜勇超
Zhang Pingying;Jiang Yongchao(Affiliated Hospital of Hubei University of Arts and Science,Pediatrics of Xiangyang Central Hospital,Xiangyang,441021)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第9期4182-4186,共5页
Genomics and Applied Biology
