摘要
目的观察支原体肺炎病儿体内Toll样受体4(TLR4)、CXCL8、可溶性髓系细胞触发受体-1(sTREM-1)水平,并分析其临床意义。方法选取2016年12月至2017年10月在郑州大学附属儿童医院接受治疗的支原体肺炎病儿100例为观察组,并按不同疾病程度再分为重症组35例和非重症组65例;选取同期接受体检的健康儿童100例为对照组。观察两组及不同疾病程度组TLR4、CXCL8、sTREM-1水平、炎症因子和肺功能指标的差异,分析各指标与炎症因子和肺功能的相关性。结果支原体肺炎病儿的TLR4[(3.48±0.67)vs.(1.03±0.02)ng/mL]、CXCL8[(288.67±12.65)vs.(148.53±19.12)pg/mL]、sTREM-1[(55.36±5.69)vs.(18.42±3.12)pg/mL]、TNF-α[(24.55±4.18)vs.(9.06±1.65)pg/mL]、IL-6[(45.25±9.58)vs.(9.06±1.65)pg/mL]、hs-CRP[(5.63±1.35)vs.(1.68±0.72)mg/L]水平均高于对照组(P<0.05),FVC、MMEF、PEF水平低于对照组(P<0.05);重症支原体肺炎病儿的TLR4、CXCL8、sTREM-1、TNF-α、IL-6、hs-CRP水平高于非重症组(P<0.05),FVC、MMEF、PEF水平低于非重症组(P<0.05);支原体肺炎病儿的TLR4、CXCL8、sTREM-1水平与炎症因子水平正相关,与肺功能水平负相关。结论支原体肺炎病儿的TLR4、CXCL8、sTREM-1水平较高,与炎症因子和肺功能指标相关,且受疾病严重程度的影响。
Objective To observe the level of TLR4,CXCL8,sTREM-1 in children with Mycoplasma pneumoniae and to analyze its clinical significance.Methods The children of Mycoplasma pneumoniae treated in our hospital from December 2016 to Octobe 2017 were selected as the research subjects,and the healthy children who received physical examination in our hospital for the same period were selected as the control.The differences of TLR4,CXCL8,sTREM-1,inflammatory factors and lung function were observed between the two groups,and the correlation of TLR4,CXCL8,sTREM-1 levels with inflammatory factors and lung function in children with mycoplasma pneumonia was analyzed.Results The levels of TLR4[(3.48±0.67)vs.(1.03±0.02)ng/mL],CXCL8 [(288.67±12.65)vs.(148.53±19.12)pg/mL],sTREM-1[(55.36±5.69)vs.(18.42±3.12)pg/mL],TNF-α[(24.55±4.18)vs.(9.06±1.65)pg/mL],IL-6[(45.25±9.58)vs.(9.06±1.65)pg/mL]and hs-CRP[(5.63±1.35)vs.(1.68±0.72)mg/L]in children with Mycoplasma pneumoniae were higher than those in the control group(P<0.05).The levels of FVC,MMEF and PEF were lower than those of the control group(P<0.05).The levels of TLR4,CXCL8,sTREM-1,TNF- a,IL-6 and hs-CRP in children with severe mycoplasma pneumonia were higher than those in non severe group(P<0.05).The levels of FVC,MMEF and PEF were lower than those of the control group(P<0.05).Conclusion The levels of TLR4,CXCL8,sTREM-1 in children with mycoplasma pneumonia are relatively high,which are related to inflammatory factors and lung function indexes,and are affected by the severity of the disease.
作者
李会娟
靳秀红
梁东阁
常会娟
LI Huijuan;JIN Xiuhong;LIANG Dongge;CHANG Huijuan(Department of Respiration,Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou,Henan 450000,China)
出处
《安徽医药》
CAS
2019年第11期2211-2214,共4页
Anhui Medical and Pharmaceutical Journal
关键词
肺炎
支原体
TOLL样受体4
可溶性髓系细胞触发受体-1
Pneumonia,mycoplasma
Toll like receptor 4
Soluble myeloid cell trigger receptor-1
Inflammatory factors
