摘要
目的比较超声影像组学(USR)方法与传统医学影像模式在诊断甲状腺乳头状癌(PTC )颈部中央区(Ⅵ区)淋巴结转移的能力差异.方法建立609例病例的训练集,通过USR方法提取筛选超声图像特征,建立加权公式以计算每一个病例的USR积分.通过统计学方法得到最佳诊断能力的USR积分作为诊断标准.建立326例病例的测试集,分别比较USR积分与超声(US)、 CT 、 US联合CT三者之间的诊断能力差异.结果测试集中USR积分诊断的准确性 0 .804 ,敏感性 0 .867 ,特异性0 .770 , ROC曲线下面积0 .766 ,约登指数 0 .533 ,明显高于 US 、 CT 、 US联合CT 的对应数值,差异具有统计学意义(均 P =0 .000).结论 USR方法得到的USR积分模型可以有效预测PTC的Ⅵ区淋巴结转移,诊断效能及临床价值明显高于传统医学影像模式.
Objective To compare the difference of diagnostic ability between ultrasound radiomics (USR) and different conventional imaging models of central neck (Ⅵ) lymph node metastasis in papillary thyroid carcinoma (PTC). Methods A training set of 609 cases was set up. USR features were extracted and screened by USR method. A weighted formula was established to calculate the USR score of each patient by ultrasound image. The USR score of the best diagnostic ability was obtained by statistical method and set as the diagnostic criterion. A test set of 326 cases was established to compare the diagnostic ability of USR score with ultrasound (US), computed tomography (CT) and US combined CT. Results The accuracy, sensitivity, specificity, area under ROC curve and Youden index of USR score in test set were 0.804, 0.867, 0.770, 0.766, 0.533, respectively, which were significantly higher than the corresponding values of US, CT and US combined CT(all P=0.000). Conclusions USR score obtained with USR method can effectively predict lymph node metastasis in Ⅵ region of PTC. The diagnostic efficiency and clinical value of USR score were significantly higher than those of conventional medical imaging models.
作者
黄云霞
周瑾
刘桐桐
郭翌
童宇洋
余锦华
汪源源
陈敏
周世崇
常才
Huang Yunxia;Zhou Jin;Liu Tongtong;Guo Yi;Tong Yuyang;Yu Jinhua;Wang Yuanyuan;Chen Min;Zhou Shichong;Chang Cai(Department of Ultrasound, Fudan University Shanghai Cancer Center & Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;Department of Electronic Engineering, Fudan University, Shanghai 200433, China;Key Laboratory of Medical Imaging, Computing and Computer-Assisted Intervention, Shanghai 200433, China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2019年第10期882-887,共6页
Chinese Journal of Ultrasonography
基金
国家自然科学基金青年项目(81401422)
上海市科学技术委员会引导项目(17411963300)
上海申康医院发展中心临床科技创新项目(SHDC22015016).
