摘要
目的观察不明原因复发性流产患者应用脂肪乳联合肝素治疗后的疗效。方法对2016年5月至2018年10月到昆明市妇幼保健院生殖中心就诊的91例不明原因的复发性流产患者进行观察研究。对照组42例患者给予阿司匹林+强的松治疗,研究组49例患者给予脂肪乳+低分子肝素治疗,对2组妊娠活产成功率、母婴不良结局及不良反应发生情况进行比较。结果(1)妊娠活产成功率:研究组为81.6%,对照组为52.4%,研究组明显高于对照组,有统计学差异(P<0.05);(2)流产、妊娠高血压疾病及死胎发生率:研究组分别为10.2%、12.2%、2.0%,明显低于对照组的33.3%、38.1%、14.3%,有统计学差异(P<0.05);(3)不良反应(过敏、血小板减少、骨质疏松):研究组发生率为18.4%,明显低于对照组的47.3%,有统计学差异(P<0.05)。结论应用脂肪乳联合肝素治疗不明原因的复发性流产临床疗效较好,即可明显提高妊娠活产成功率,又可改善母婴结局,其不良反应的发生率也较低,用药安全,疗效可靠,值得在临床应用与推广。
Objective To observe the clinical effect of intralipid combined with heparin in the patients with unexplained recurrent abortion. Methods From May 2016 to October 2018, 91 patients with unexplained recurrent abortion treated in our center were randomly divided into two groups. Patients in the control group(n = 42)were treated with aspirin plus prednisone, while those in the study group(n = 49) were treated with intralipid combined with heparin. Results(1)The success rate of pregnancy was 81.6% in the study group,which was significantly higher than that in the control group (52.4%), with statistical difference(P < 0.05).(2)The incidence of abortion, pregnancy hypertension and stillbirth in the study group respectively were 10.2%, 12.2% and 2.0%,which were significantly lower than 33.3%, 38.1% and 14.3% in the control group, with statistical differences (P < 0.05).(3)The incidence of adverse reactions, such as allergy, thrombocytopenia and/or osteoporosis in the study group was 18.4%, which was significantly lower than that in the control group(47.3%),with statistical difference(P < 0.05). Conclusion Intralipid combined with heparin is effective in the treatment for patients with unexplained recurrent abortion. It can significantly advance the success rate of pregnancy,improve maternal and infant outcome, and has a lower incidence of adverse reactions. Therefore, it is worthy of clinical application and promotion.
作者
蔡金凤
肖彭莹
姚颖杰
CAI Jin-feng;XIAO Peng-yIng;YAO Ying-jie(Dept.of Kunming Maternal and Child Health Hospital,Kunming Yunnan 650031,China)
出处
《昆明医科大学学报》
CAS
2019年第10期106-108,共3页
Journal of Kunming Medical University
基金
云南省应用基础研究基金资助项目（2012FD099）
