摘要
目的分析小儿咳嗽变异性哮喘联合应用孟鲁司特钠与布地奈德治疗的效果与安全性。方法于2016年9月至2018年10月开封市儿童医院收治的小儿咳嗽变异性哮喘患儿中选取140例,随机分为两组,对照组采用布地奈德雾化吸入治疗,研究组在此基础上加用孟鲁司特钠治疗,比较两组治疗效果。结果研究组治疗后的一秒用力呼气量(FEV1)(2.64±0.36)L,FEV1/FVC为(84.56±2.38)%,与对照组的(1.98±0.27)L和(78.34±1.97)%比较,均有显著性差异(P<0.05)。研究组治疗总有效率为95.7%,明显高于对照组的80.0%,差异有统计学意义(P<0.05)。研究组不良反应发生率为2.8%,对照组发生率为14.3%,组间对比有统计学差异(P<0.05)。结论小儿咳嗽变异性哮喘在应用布地奈德治疗的同时,结合孟鲁司特钠治疗可有效改善患者肺功能,提高临床治疗效果,且不良反应少,具有较高疗效与安全性。
Objective To analyze the efficacy and safety of montelulast sodium combined with budesonide in the treatment of cough variant asthma in children.Methods Totally 140 children with pediatric cough variant asthma admitted to Kaifeng Children’s Hospital from September 2016 to October 2018 were randomly divided into two groups. The control group was treated with budesonide atomization inhalation, and the research group was treated with montelukast sodium to compare the therapeutic effects of the two groups.Results After treatment, FEV1(2.64±0.36) L and FEV1/FVC(84.56±2.38)% in the study group were significantly different from(1.98±0.27) L and(78.34±1.97)% in the control group(P<0.05). The total effective rate of the study group was 95.7%, which was significantly higher than that of the control group(80.0%, P<0.05). The incidence of adverse reactions was 2.8% in the study group and 14.3% in the control group, with statistically significant differences between the two groups(P<0.05).Conclusion In addition to budesonide, montelulast sodium can effectively improve the pulmonary function of children with cough variant asthma and improve the clinical therapeutic effect.
作者
曹海丽
CAO Hai-li(Kaifeng Children's Hospital,Henan Kaifeng 475000,China)
出处
《医药论坛杂志》
2019年第9期92-94,共3页
Journal of Medical Forum
