摘要
对100例乳腺癌选用ER和PR抗血清,采用ABC法进行免疫组化染色,结果发现:ER和PR同时阳性者为40例(40％),ER和PR同时阴性者为26例(26％);所有病例随访3～4年,40例ER和PR同时阳性中有1例复发,占2.5％,26例ER和PR同时阴性中有12例复发,占46.2％,二者有显著差异性(P<0.01)。结果提示:乳腺癌ER和PR同时阳性病预后较阴性病例好,因此,同时测定乳腺癌ER和PR对临床制定乳腺癌的治疗方案和判定预后有重大价值和意义。
Breast cancer specimens from 100 patients were stained for the estrogen receptors (ER) and progestin receptors (PR) by the Avidin-Biotin Peroxidase-Complex (ABC) immunohistochemistry method. The results showed that both ER and PR were positive in 40 cases(40%), Both negative in 26 cases(26%). During 3 to 4 years follow-up period, one of 40 cases with ER and PR positive presented with recurrences (2.5%), whereas 12 of 26 cases with ER and PR negative group recured (46.2%). This differnce is significant (p<0.01). These results indicats that breast cancer patients with simultaneous ER and PR positive have a better prognosis than those negative patients. Therefore, the simultaneous measurement of ER and PR has the adrantages for taking clinical therapy and estimating prognosis of breast cancer.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第2期123-126,共4页
Chinese Journal of Cancer
关键词
乳腺癌
雌激素受体
孕激素受体
Breast Cancer Estrogen receptors Progestin receptors
