摘要
用顺铂(CDDP,100mg/m^2)、异环磷酰胺(IFX,2g/m^2×3,合并Mcsna)和长春酰胺(VDS,3mg/m^2)联合化疗方案(CIV)治疗47例不能手术的非小细胞肺癌。3周或5周重复一次。40例可评价的病人,19例(47.5％) 获部分缓解(PR)(其中鳞癌78.6％、腺癌30.1％),没有完全缓解(CR)病例。本方案的血液学毒性不严重,但是,肾毒性相当高,2例病人发生肾功能衰竭,随后死于全血细胞减少症和脓毒血症。作者认为,对于非小细胞肺癌,特别是鳞癌,CI方案比CDDP+VDS更有效,但是,所治疗的病人应经严格选择。
A total of 47 patients with unresectable non small-cell lung cancer were treated with a regimen consisting of cisplatin (CDDP, 100mg/ m2 ) ,ifosfamide (IFX,2g/ m2 × 3 ; with mesna) and vindestoe (VDS, 3mg/ m2 ) (CIV) . This regimen was given over a 3-or 5-week period Among 40 completely evaluable patients, 19 partial responses (PRs) w ere observed , for a response rate of 47.5% (78.6% in squamous-cell aarcinoma and 30.1%in adeno-and large-cell carcinoma) ; no complete responses (CRs) were obtained.The hemato-logic toxkity was not severe, but the renal toxicity was rather high; two patients developed acute renal failure and died of subsequent pancytopenia and sepsis. We concluded that the CIV regimen was more effective, especially against squamous-cell carcinoma, but more toxic than the combination of CDDP and VDS for non-small-cell lung cancer and that candidates for this therapy must be carefully chosen.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第3期184-186,242,共4页
Chinese Journal of Cancer
