摘要
目的探讨低剂量米非司酮治疗子宫内膜异位症的疗效。方法 2 2例子宫内膜异位症患者口服米非司酮 12 .5 mg,1次 /d,连续3～ 6个月。比较治疗前后症状、体征及血激素水平。结果在治疗期间所有患者均闭经 ,与治疗前比较 ,总主观症状评分于治疗 3个月后下降了 82 .6% ,6个月后下降了 93 .5 % (P<0 .0 1) ;内膜异位症病灶于 3个月后缩小了 3 2 .8% ,6个月后缩小了 5 8.2 % (P<0 .0 1)。用药 3个月血孕激素水平比用药前显著降低 ,雌激素水平降至卵泡中期水平 ,黄体生成素、促卵泡激素水平均无变化。停止治疗后于2 4～ 40天恢复月经。不良反应为潮热、恶心及乏力。结论低剂量米非司酮治疗子宫内膜异位症效果良好 ,副作用小 。
Objective To explore the efficacy of low dose mifepristone in treating endometriosis.Methods 22 patients with endometriosis were treated by oral mifepristone 12.5mg/d,once a day,for 3～6 months.The comparison of signs,symptoms and the level of serum hormone before and after treatment was made.Results During treatment,menstruation of all the patients stopped.As compared with that before treatment,total subjective symptom scores decreased by 82.6% after 3 months treatment and decreased by 93.5%after 6 months treatment (P<0.01) .The endometriosis focal was reduced by 32.8%3 months later and by 58.2%5 months later(P<0.01).3 months later after using mifepristone,serum level of progestogen significantly decreased as compared with that before treatment.Estrogen level reduced to be the same as in middle follicle phase,but luteinizing hormone and menotropin had no change.24～40 days after treatment was stopped,menstruation restarted.The main side effects were hot flush,nausea and weakness.Conclusion Low dose of mifepristone is effective and safe in treating endometriosis,with little side effects,which is another conventional way to treat endometriosis.
出处
《中国综合临床》
北大核心
2002年第11期1038-1039,共2页
Clinical Medicine of China
