摘要
目的:探讨前哨淋巴结活检(sentinellymphnodebiopsy,SLNB)在乳腺癌临床应用中的可行性、准确性。方法:术前肿瘤表面或活检腔周围皮内注射99mTc-DX,进行前哨淋巴结(sentinellymphnode,SLN)显像、体表定位;术中r-探测仪识别SLN,先行SLNB,再行乳腺癌根治术或改良根治术,术后对SLN和腋窝淋巴结清扫(axillaryLymphNodeDissection,ALND)的病理结果进行综合分析。结果:淋巴闪烁显像和r-探测器联合应用检测SLN准确率为96.9%,敏感度为90.9%,假阴性率为9.1%,假阳性率为0。结论:SLNB是乳腺癌治疗中的一项新技术,能高灵敏度反应腋淋巴结状态。
Objective:To assess the feasibility and accuracy of sentinel lymph node biopsy(SLNB)in breast cancer.Methods:Thirty-three cases of stage T 1～2 ,N 0～1 abreast cancer were en-rolled.After radiolabeled material(99mTc-DX)were injected intracutaneously surrounding the pri-mary tumor or adjacent to the biopsy scar,the sentinel lymph nodes(SLN)were identified by lym-phoscintigraphy and labeled on skin of body.At surgery,using the hand-held gamma probe,the radiolabeled axillary lymph nodes(included SLN)could be detected and SLNB were performed be-fore the radical/modified mastectomy.The radioactive content and histopathology of the individu al lymph node harvested during each procedure were analyzed.Results:Combining lymphoscintig ra-phy and gamma probe,the detection rate was96.9%,sensitivity was90.9%,false negative was9.1%and false positive was0.Conclusion:SLNB has an important value for the treatment of breast cancer in clinic.It almost has not any injury and has a high accuracy and sensitivity in prediction of axillary lymph nodes metastasis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第10期723-725,共3页
Chinese Journal of Clinical Oncology
关键词
乳腺癌
前哨淋巴结
临床研究
淋巴闪烁显像
r-探测器
Sentinel lymph node Lymphoscintigraphy Gamma probe Lymphatic metastasis Breast cancer
