摘要
慢性病贫血 (ACD)的发病是由于铁代谢障碍、红细胞生成素 (EPO )分泌减少和细胞因子导致的骨髓对贫血的代偿不足引起 ,其诊断依据是 :(1)正常细胞性贫血或小细胞低色素性贫血 ;(2 )血清铁低、总铁结合力正常或降低 ,铁蛋白增多 ;(3 )骨髓铁染色显示幼红细胞内铁颗粒减少 ,巨噬细胞内铁颗粒增多 ;(4 )排除基础性疾病合并的症状性贫血。ACD的鉴别诊断应排除系统疾病症状性贫血及缺铁性贫血。ACD的治疗除治疗基础疾病外 ,可用EPO治疗。
The anemia of chronic disease (ACD) is a kind of anemia caused by abnormal iron metabolism,cytokines induced lower EPO level and impaired marrow response to EPO and anemia.The diagnosis of ACD is based on:(1)normocytic anemia or microcytic anemia;(2) serum iron concentration decrease,total iron binding capacity is normal or reduced, serum ferritin increase;(3)in bone morrow aspirates stained for iron,the number of sideroblasts is reduced,and the amount of hemosiderin in macrophages is increased;(4)excluding the anemia of caused by underline diseases and the iron deficiency anemia.EPO treatment is recommended for ACD besides treating the original disease.
出处
《临床内科杂志》
CAS
北大核心
2002年第6期407-408,共2页
Journal of Clinical Internal Medicine
