摘要
目的 :比较采用每周 1次与每天 1次噻萘普汀治疗长期抑郁症的临床疗效。方法 :将 6 4例已接受每天 1次噻萘普汀治疗且临床疗效已达显著进步或痊愈的长期性忧郁症病人 ,随机分为研究组 (31例 )和对照组 (33例 ) ,研究组前 2周改为每周 2次噻萘普汀治疗 ,第 3周开始改为每周 1次噻萘普汀治疗 ;对照组继续每天 1次噻萘普汀治疗 ,疗程 3个月。均符合CCMD - 3抑郁症 ,双相情感性精神障碍 ,抑郁相诊断标准 :Hamilton抑郁量表 (HAMD)和副反应症状量表 (TESS)评定疗效和药物不良反应。结果 :研究组仅 1例失败而更改治疗方案 ,研究组与对照组维持治疗前后组内和组间HAMD评分比较都无显著差异。结果 :经过急性期治疗临床已经好转的 ,但反复发作 ,不能适应社会、生活及生理功能等方面的抑郁症病人 ,采用噻萘普汀每周 1次的治疗方案 ,同样可以维持原有的疗效。
Objective: To compare the efficacy of daily and once-weekly dose of Talinol in the maintenance treatment of long term depression. Method: After being treated initially with daily doses of Tatinol and having been improved,64 patients with long term depression were randomly assigned to study group(u=31)and control group(n=33)for 3 months.The study group,was switched to twice-weekly does in the first and second week,and was switched to once-weekly dose from the third week.The control group continued daily dose regimen.They all met CCMD-3 depression,bipolar affective mental disorder,criteria for depression,HAMD and TESS. Results: Only one patient in the study group,was switched therapy plan.There were no significant differences in HAMD scores in two group's before and after the maintenance treatment. Conclusion: It suggests that once-weekly Tatinol dose is effective in the maintenance treatment of the patients with depression.
出处
《中国民政医学杂志》
2002年第6期339-340,共2页
Medical Journal of Chinese Civil Administration
