摘要
目的 :研究南沙参多糖对亚慢性照射引发小鼠辐射损伤的保护作用。方法 :小鼠灌服南沙参多糖 ,用60 Coγ射线全身低剂量均匀间断照射 10 6d ,累计吸收剂量为 3 2 5Gy ,检测体重变化、丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)活力、免疫器官脏器指数、全血中硒 谷胱甘肽过氧化物氧化酶 (Se GSH Px)活力、血清谷丙转氨酶 (GPT)及谷草转氨酶 (GOT)活力。结果 :辐射损伤后小鼠体重增加幅度下降、脾和胸腺指数下降、MDA含量增高、SOD及GSH Px活力下降、GPT和GOT活力增加。南沙参多糖可促进上述指标恢复。结论 :南沙参多糖对亚慢性受照损伤小鼠有明显的保护作用 ,其机制可能与抗氧化活性有关。
Objective: To study the effects of Radix adenophorae potanini korsh polysaccharides (RAPS) on sub-chronic radiation injury in mice. Methods: The mice were radiated intemittently by ~ 60Goγ-rays for 106 days at the total absorption doses of 3.25Gy, at the same time these mice were treated orally in the 0.5?1.0 and 2.0g/kg of RAPS. Then body weight?contents of MDA?spleen/body weight?thymus/body weight and activities of SOD?Se-GSH-Px?GPT?GOT were measured. Results: After radiation injury, RAPS could prevent the elevation of body weight?spleen/body weight?thymus/body weight; contents of MDA increased obviously; activities of SOD and GSH-Px decreased remarkablely; activities of GPT?GOT increased. Conclusion: RAPS has certain protective effects on sub-chronic irradiated mice, the mechanism of which may related with antioxidation.
出处
《中药药理与临床》
CAS
CSCD
2002年第5期21-23,共3页
Pharmacology and Clinics of Chinese Materia Medica
