摘要
本文对21例偏头痛患者血小板和血浆5-HT含量和血小板聚集率在发作期和间歇期的变化做了观察,结果表明:偏头痛患者血小板5-HT含量无论是发作期还是间歇期,与对照组比较均显著增高(P均<0.01);血浆5-HT含量在发作期显著低下(P<0.01),而间歇期显著增高(P<0.01);血小板和血浆5-HT比值在发作期明显增高(P<0.01),间歇期无明显变化(P>0.05)。血小板诱导聚集在发作期和间歇期与对照组比较均无明显差异(P均>0.05)。我们认为偏头痛患者血小板和血浆5-HT含量及比值异常可能与其发病机理有关。
In this paper, the change of 5-HT contents in platelet and plasma, as well as aggregation rate of platelets of 21 migraineurs were investigated. The results showed that the platelet 5-HT contents of migraineurs were substantially increased in comparison with those of controls during an attacks or haedache-free period (P<(0.01). The plasma 5-HT contents were significantly lower during an attacke(P<(0.01), and higher during headachefree period (P<(0.01). The difference of platelets aggregation induced by ADP between migraineurs and controls were not marked, during attacke and headache-free periods (P>0.05). We believed that the platelets and plasma 5-HT contents and their ratio in migraineuns may be involved in the pathogensis of migraine.
出处
《北京医学》
CAS
北大核心
1992年第3期134-136,共3页
Beijing Medical Journal
