摘要
通过已构建的THP1-Lucia/NF-κB细胞筛选系统,对岩藻黄素、虾青素、β-胡萝卜素和玉米黄质等4种海洋来源的类胡罗卜素化合物进行抗炎活性筛选,结果发现岩藻黄素具有良好的抗炎活性.在此基础,进一步研究岩藻黄素对NF-κB信号通路的调控机制,结果揭示了岩藻黄素能通过抑制IκB-α的细胞质降解和NF-κB蛋白的磷酸化,进而抑制由LPS诱导的细胞炎症因子的产生,从而达到抗炎效果.
In this study,four marine-derived carotenoid compounds,such as fucoxanthin,astaxanthin,β-carotene and zeaxanthin,were tested using the established THP1-Lucia/NF-κB cell screening system.Screening for anti-inflammatory activity revealed that fucoxanthin has good anti-inflammatory activities.On this basis,the regulation mechanism of fucoxanthin on NF-κB signaling pathway was further studied.The results revealed that fucoxanthin inhibited the cytoplasmic degradation of IκB-αand phosphorylation of NF-κB,so that the production of cellular inflammatory factors induced by LPS were inhibited.
作者
刘逸煊
刘家伶
郭凯
黄敏
黄鹭强
彭家礼
陈由强
苏经迁
LIU Yi-xuan;LIU Jia-ling;GUO Kai;HUANG Min;HUANG Lu-qiang;PENG Jia-li;CHEN You-qiang;SU Jing-qian(Biomedical Research Center of South China,Fujian Normal University,Fuzhou 350117,China;College of Life Sciences,Fujian Normal University,Fuzhou 350117,China;Fujian Key Laboratory of Innate Immune Biology,Fujian Normal University,Fuzhou 350117,China;Southern Institute of Oceanography,Fujian Normal University,Fuzhou 350117,China;Center of Engineering Teacnology Research for Microalgae Germplas Improvement of Fujian,Fuzhou 350117,China;Institute of Marine Biology and Center of Excellence for the Oceans,Taiwan Ocean University,Taibei 20224,China)
出处
《福建师范大学学报（自然科学版）》
CAS
北大核心
2019年第2期89-96,共8页
Journal of Fujian Normal University：Natural Science Edition
基金
国家自然科学基金资助项目(81803547)
国家海洋渔业局"十三五"海洋经济创新发展示范项目(FZHJ14)
福建省自然科学基金面上项目(2018J01720)
福建师范大学创新团队项目(IRTL1703)
福建师范大学生命科学学院科研扶持计划项目(FZSKG2018013)
