摘要
氟中毒导致神经系统损伤越来越受到氟病研究者的重视。氟中毒可导致患者记忆力减退,引起儿童智商减低和认知功能障碍等神经系统损伤的行为学表现。氟中毒神经损伤机制涉及氧化应激、信号转导和神经递质及受体改变等方面。氧化应激是氟中毒性神经损伤机制的中心环节,有研究提示除了一些抗氧化的药物和制剂,作为食品的黑蒜,同样具有抗氧化等很多生物学功效。本文根据黑蒜的抗氧化应激和神经保护作用进行了分析、推论,提示黑蒜可能对氟中毒神经损伤具有保护作用,其作用效果及机制尚有待进一步研究。
The damage of nervous system caused by fluorosis has been paid more and more attention.Fluorosis can lead to memory loss,mental retardation and cognitive deficits in children.Advance in the understanding of the mechanism of fluorosis induced nervous system damage will be summarized here from several aspects,including oxidative stress,signal transduction and neurotransmitters and receptors.Oxidative stress is the central link in the mechanism of fluorotoxic nerve damage.Studies have suggested that in addition to some antioxidant drugs and preparations,black garlic,which is a food,has many biological effects such as antioxidants.It suggested that black garlic may have protective effects on fluorosis nerve injury through analyzing the antioxidant property and neuroprotective effects of black garlic,further studies are needed to address the effect and the underlying mechanism of black garlic.
作者
张一彤
张忠玲
Zhang Yitong;Zhang Zhongling(Department of Neurology,the First A ffiliaied Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2019年第7期597-602,共6页
Chinese Journal of Endemiology
关键词
氟中毒
神经系统
黑蒜
氧化应激
Fluorosis
Nervous system
Black garlic
Oxidative stress
