摘要
背景:骨形态发生蛋白9作为成骨诱导生长因子已经被证实为骨形态发生蛋白家族中成骨能力最强的生长因子。目的:探讨骨形态发生蛋白9的诱导成骨机制及其应用的研究进展。方法:作者在Web of Science、PubMed、万方、中国知网中以"bone morphogenetic protein9/BMP9,bone ingrowth,bone tissue engineer,osteogenic differentiation";"骨形态发生蛋白9,细胞因子"为关键词,检索1989年至2019年期间的文献。排除无关及重复文献,详细地进行分析与综述。结果与结论:目前为止,骨形态发生蛋白9已经被证实是14种骨形态发生蛋白家族中在体外和体内诱导间充质干细胞成骨分化方面最有效的生长因子之一,并且,骨形态发生蛋白9在骨与软骨损伤的修复过程及促进成骨分化当中扮演着重要的角色。骨形态发生蛋白9也被称为生长分化因子2,其诱导成骨分化机制非常复杂,其信号传导通路涉及到了各种成骨信号通路,各种生长调控因子也参与进骨形态发生蛋白9诱导成骨的全部过程,且其成骨机制与其他骨形态发生蛋白家族成员的成骨机制具有差异。在各种动物实验中,骨形态发生蛋白9可以促进骨折的愈合、软骨的生成、脊柱融合等。因此,骨形态发生蛋白9在应用基础研究中具有非常大的潜能。
BACKGROUND: Bone morphogenetic protein 9 has been proven to be the strongest osteogenic growth factor in the bone morphogenetic protein family. OBJECTIVE: To explore the research progress of bone morphogenetic protein 9 induced osteogenic mechanism and its application. METHODS: Web of Science, PubMed, WanFang and CNKI were searched using “bone morphogenetic protein9/BMP9, bone ingrowth, bone tissue engineering, osteogenic differentiation, cytokines” as key words for relevant articles published from 1989 to 2019. A comprehensive analysis and review was performed after removal of irrelevant and repetitive literature. RESULTS AND CONCLUSION: To date, bone morphogenetic protein 9 has been shown to be one of the most potent growth factors for inducing the osteogenic differentiation of mesenchymal stem cells in vitro and in vivo in the 14 bone morphogenetic protein family members. Moreover, bone morphogenetic protein 9 plays an important role in the repair of bone and cartilage damage and in promoting osteogenic differentiation. Bone morphogenetic protein 9 is also known as growth differentiation factor 2, and its mechanism underlying osteogenic induction is very complicated. Its signaling pathway involves various osteogenic signaling pathways, and various growth regulators are also involved in the entire osteogenic induction by bone morphogenetic protein 9. The osteogenic mechanism of bone morphogenetic protein 9 is different from the osteogenesis mechanism of other bone morphogenetic protein family members. In animal experiments, bone morphogenetic protein 9 can promote fracture healing, cartilage formation, and spinal fusion. Therefore, bone morphogenetic protein 9 has a great potential in basic research.
作者
朱正清
陈香润
贾方腾
黄岚峰
Zhu Zhengqing;Chen Xiangrun;Jia Fangteng;Huang Lanfeng(Department of Orthopedics,Second Hospital of Jilin University,Changchun 130041,Jilin Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第33期5404-5412,共9页
Chinese Journal of Tissue Engineering Research
基金
吉林省财政厅卫生专项项目(201817294302),项目负责人:黄岚峰~~
关键词
骨形态发生蛋白9
骨诱导
骨再生
骨长入
成骨分化
间充质干细胞
bone morphogenetic protein 9
osteogenic induction
bone regeneration
bone ingrowth
osteogenic differentiation
mesenchymal stem cells
