摘要
目的分析广州市居民碘营养状态与甲状腺结节疾病临床特征的关联。方法收集自2018年1月1日至2019年2月1日在广州医科大学附属第二医院就诊的成人人群,且同期行甲状腺B超、尿碘以及甲状腺功能相关检查者;根据尿碘水平进行评判分组,尿碘<100μg/L为碘营养不足组;尿碘100~199μg/L为碘营养适宜组;尿碘200~299μg/L为碘营养超适宜量组;尿碘>300μg/L为碘营养过量组。观察尿碘与甲状腺疾病患病率和甲状腺功能的关系。结果研究共入组观察1107例,尿碘中位数93.40μg/L,其中甲状腺结节患者309例,与碘适量组甲状腺结节患病率比较,其他不同的碘营养组甲状腺结节患病率无显著性差异,碘营养水平对甲状腺结节合并甲亢或自身免疫性甲状腺炎的患病率亦无显著影响;与碘适量组人群相比,碘营养不足和碘过量组FT3和FT4显著增高,而对应TSH水平显著下降。结论广州市居民成人碘营养偏低,碘营养水平不足或过量均可能导致甲状腺功能异常。
Objective To analyze the relationship between iodine nutritional status and clinical fea.tures of thyroid nodule disease in Guangzhou residents.Methods The adult population was collectedfrom the Second Affiliated Hospital of Guangzhou Medical University from January 1,2018 to February1,2019.Thyroid ultrasound,urinary iodine and thyroid function were detected in subjects.Urinary iodine<100μg/L was for iodine insufficient group;urinary iodine 100-199μg/L for iodine adequate group;urine iodine 200-299μg/L for above requirement group;urine iodine>300μg/L for the iodine excessgroup.The relationship between urinary iodine and thyroid disease and thyroid function was explored.Results A total of 1107 patients were enrolled in the study,including 309 patients with thyroid nodules.The median urinary iodine was 93.40μg/L.Compared with the iodine adequategroup,there was nosignificant difference in the rate of thyroid nodule disease in other groups.Besides,iodine nutrient hadno significant effect on the prevalence of thyroid nodules complicated with hyperthyroidism or autoimmunethyroiditis.Compared with the iodine adequate group,iodine insufficient and iodine excess group showedsignificant higher FT3 and FT4 levels,and corresponding significantly lower TSH level.ConclusionThe iodine nutrition of adults in Guangzhou is insufficient,and both iodine deficiency and iodine excesscould lead to abnormal thyroid function.
作者
温小芳
曾楠
区婷婷
李万根
杜弢
WEN Xiaofang;ZENG Nan;OU Tingting;LI Wan′gen;DU Tao(Department of Endocrinology,The Second Affiliated Hospital,Guangzhou Medical University,Guangzhou510260,China)
出处
《岭南现代临床外科》
2019年第4期383-386,共4页
Lingnan Modern Clinics in Surgery
基金
广东省科技计划项目(2016A030303066)
广州市科技计划项目(201607010036)
关键词
碘营养
尿碘
甲状腺结节
成人
广州
iodine nutritional status
urine iodine
thyroid nodule
adults
Guangzhou
