摘要
目的探讨高危型人乳头瘤状病毒(HPV)感染与常见特异性阴道炎的相关性。方法收集2017年1月-2017年12月在河北省定州市人民医院妇科就诊同时进行液基薄层细胞(TCT)及HPV检测7 936例受试者的相关资料,分析细菌性阴道炎、滴虫阴道炎及霉菌性阴道炎患者与正常者HPV阳性率的差异。结果细菌性阴道炎组HPV感染率32.09%,滴虫阴道炎组HPV感染率18.65%,霉菌性阴道炎组HPV感染率11.79%,正常对照组HPV感染率12.99%,细菌性阴道炎组与正常对照组HPV感染率差异有统计学意义(χ^2=180.43,P<0.05),滴虫阴道炎组与正常对照组HPV感染率差异有统计学意义(χ^2=5.10,P<0.05),霉菌性阴道炎患者与正常对照HPV感染率差异无统计学意义(χ^2=0.57,P>0.05)。结论细菌性阴道炎患者及滴虫阴道炎患者更容易感染HPV病毒引起宫颈上皮内病变,霉菌性阴道炎患者与正常者感染HPV的概率无明显差异。细菌性阴道炎患者及滴虫阴道炎患者不仅要治疗相应阴道炎,还要做HPV筛查,必要时做阴道镜检查排除宫颈上皮内病变,霉菌性阴道炎者应密切随访,避免过度治疗。
Objective To investigate the correlation between high-risk human papillomavirus(HPV)infection and common specific vaginitis.Methods A total of 7 936 healthy volunteers were selected from department of gynecology in Dingzhou People's Hospital of Hebei Province from January 2017 to December 2017,then thinprep cytologic test(TCT)and HPV detection simultaneously were carried out.The difference of HPV infection rate between patients with bacterial vaginosis,trichomonas vaginitis and mycotic vaginitis and normal persons was analyzed.Results HPV infection rate was 32.09%in bacterial vaginosis group,18.65%in trichomonas vaginitis group,11.79%in mycotic vaginitis group and 12.99%in normal control group.There was statistically significant difference in HPV infection rate between bacterial vaginosis group and normal control group(χ^2=180.43,P<0.05).There was statistically signifcant diference in HPV infection rate between trichomonas vaginitis group and control group(χ^2=5.10,P<0.05).There was no statistically signifcant diference in HPV infection rate between mycotic vaginitis patients and control group(χ^2=0.57,P>0.05).Conclusion Patients with bacterial vaginosis and trichomonas vaginitis are more susceptible to HPV infection and cause cervical intraepithelial lesions.There is no signifcant diference in the probability of HPV infection between mycotic vaginitis patients and normal person.Patients with bacterial vaginosis and trichomonas vaginitis should not only treat the corresponding vaginitis,but also do HPV screening.If necessary,colposcopy should be done to exclude cervical intraepithelial lesions.Patients with mycotic vaginitis should be closely followed up to avoid overtreatment.
作者
陈平莲
李超
CHEN Pinglian;LI Chao(Department of Pathology,People's Hospital of Dingzhou,Dingzhou Hebei 073000,China)
出处
《中国继续医学教育》
2019年第22期78-80,共3页
China Continuing Medical Education
