摘要
目的探讨动脉瘤性蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)患者垂体前叶功能减退发生情况,与临床病情的相关性及随访期间变化情况。方法回顾性分析48例aSAH患者发病后3天、1周、3周、3月和6月的垂体前叶激素分泌情况,并分析与改良Fisher分级、Hunt-Hess分级的相关性。结果aSAH后3月和6月出现ACTH和GH降低,改良Fisher分级4级患者ACTH水平降低,改良Fisher分级3级和4级患者GH水平降低,Hunt-HessⅣ~Ⅴ级患者GH水平降低。结论aSAH恢复期出现ACTH和GH降低,与改良Fisher分级、Hunt-Hess分级有相关性。
Objective To explore the risk of anterior pituitary hormones after aneurysmal subarachnoid hemorrhage(aSAH)and to evaluate its correlation with clinical data and follow-up.Methods 48 cases of patients with aSAH were retrospectively analysed.Serum adrenocorticotrophic hormone(ACTH),growth hormone(GH),thyroid stimulating hormone(TSH),follicle-stimulating hormone(FSH),luteinizing hormone(LH),and prolactin(PRL)were dynamic tested 3days,1week,3weeks,3months,6months after the onset.Results ACTH and GH deficiency were the most frequent disorder at the 3months and 6months follow-up.ACTH and GH deficiency were related to Fisher grade and Hunt-Hess system.Conclusion The incidence of anterior pituitary hormones after aSAH was rear and related to the severity of patientsand affect the prognosis.
作者
陈钰
邵波
陈慧慧
何玺君
彭余江
杨帆
滕灵方
CHEN Yu;SHAO Bo;CHEN Huihui(The First People's Hospital of Wenling,Zhejiang 317500,China)
出处
《浙江创伤外科》
2019年第4期659-662,共4页
Zhejiang Journal of Traumatic Surgery
基金
浙江省医药卫生科技计划项目(2017KY721)
浙江省中医药科技计划项目(2018ZB139)
浙江省台州市科技计划项目(1601KY42)资助
