摘要
干扰素诱导的跨膜(Interferon-induced transmembrane,IFITM)蛋白家族和干扰素诱导(Interferon-induced proteins with tetratricopeptide repeats,IFIT)蛋白家族作为受干扰素所诱导的,执行抗病功能的家族,在免疫反应中扮演着至关重要的角色;特别是IFIT5是家禽体内存在唯一的IFIT家族成员。IFITM通过抑制病毒包膜与宿主细胞膜的融合,从而抑制病毒的入侵;而IFIT则是抑制病毒的转录与复制,阻断病毒繁殖,从而抑制病毒的感染。两者在生物体内协同发挥抗病毒功能,清除病毒,保护宿主细胞正常的生理活动。在数万年的进化中,病毒也进化出相应的机制来逃避免疫蛋白的抑制。文章就IFITM和IFIT基因家族抗病毒机制的研究进展进行总结,为之后的研究提供参考。
Interferon-induced transmembrane(IFITM)protein family and interferon-induced proteins with tetratricopeptide repeats(IFIT) protein family as induced by interferon, perform the function of disease-resistant, and play a vital role in the immune reaction. In particular, IFIT5 is the only member of the IFIT family in poultry. IFITM inhibits virus invasion by inhibiting the fusion of virus envelope and host cell membrane. However, IFIT interrupt the transcription and replication of the virus and thus inhibits virus reproduction. The two synergistically play the antiviral function, remove the virus, and protect the normal physiological activities of the host cells. Over tens of thousands of years of evolution,viruses have evolved mechanisms to evade the suppression of immune proteins. This paper summarizes the research progress of the antiviral mechanism of IFITM and IFIT gene family, and provides reference for future research.
作者
张贝
郝文文
耿立英
彭永东
张传生
李祥龙
ZHANG Bei;HAO Wenwen;GENG Liying;PENG Yongdong;ZHANG Chuansheng;LI Xianglong(College of Agronomy and Biotechnology,Hebei Normal University of Science&Technology,Changli,Hebei 066600;College of Animal Science and Technology,Hebei Normal University of Science&Technology,Changli,Hebei 066600)
出处
《中国家禽》
北大核心
2019年第14期55-59,共5页
China Poultry
基金
河北省教育厅重点项目(ZD2018225)
河北科技师范学院博士启动基金(2018YB002)
河北省现代农业产业技术体系蛋鸡产业创新团队岗位项目(HBCT2013090206)
