摘要
针对高结构相似度同系物中特定化合物的检测分析流程复杂的问题,采用模块化组装的策略制备了一类嵌含光学分子探针的超分子囊泡,并在此基础上建立了一种集分离与检测功能于一体的新型荧光传感模式.将生物硫醇的广普性探针四氟对苯二甲腈嵌入由四(戊硫代)四硫富瓦烯与十二烷基-β-D-麦芽糖苷构成的超分子囊泡膜层后,囊泡对半胱氨酸展现出高选择性、宽动态范围的荧光响应,实现了半胱氨酸的便捷、灵敏检测.由四烃基四硫富瓦烯和表面活性剂共组装形成的空白囊泡制备简单,光谱可见光区背景吸收低,可作为构建此类荧光传感体系的通用模板,为这种新型传感模式的推广提供有力的支撑.
It is usually necessary to involve a complex and time-consuming analytical procedure in detecting target species with high selectivity over its structurally-similar homologues.In order to solve the problem,probe-interbedded supramolecular vesicles(PISVs)had been fabricated via modular self-assembly and employed to develop a new fluorescent sensing mode possessing both separation and quantitation functions.As a general fluorescent probe for biothiols,tetrafluoroterephthalonitrile(4 F-2 CN)was found to show highly selective and wide-dynamic-range response for cysteine(Cys)over homocysteine(Hcy),penicillamine(Pen)and glutathione(GSH),when interbedded in the supramolecular vesicles assembled from tetrakis(pentylthio)tetrathiafulvalene(TPT-TTF)and ndodecyl-β-D-maltopyranoside(DDM),so that straightforward and sensitive fluorescent sensing of Cys was established.The noninterbedded vesicles formed by TPT-TTF and common amphiphiles were facilely prepared and displayed a low spectral background in visual region,offering ageneral and efficient vesicle template for developing other PISV-based sensing systems.
作者
王月敏
李顺华
WANG Yuemin;LI Shunhua(Key Laboratory of Spectrochemical Analysis&Instrumentation,Ministry of Education,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China)
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
2019年第5期637-642,共6页
Journal of Xiamen University：Natural Science
基金
国家自然科学基金(21775129,21475111)
关键词
囊泡
荧光探针
分子自组装
半胱氨酸
vesicles
fluorescent probes
molecular self-assembly
cysteine
