摘要
衰老是生物体的必然结局。延缓衰老延长寿命、减少老年病改善老年人生活质量一直是人们的研究热点。构建衰老动物模型,使实验动物呈现与人类相似的衰老表型,是研究人类衰老机制和研发抗衰老药物的重要手段。目前广泛应用的衰老模型,涵盖了从果蝇、线虫等无脊椎动物,到小型鱼类、啮齿动物和非人灵长类等等。近年来,各种基因修饰小鼠在研究衰老发生、发展及干预评价中起到重要作用;另外在常规模式动物之外,选用寿命不同的生物以及寿命差异较大的同一物种,进行寿命相关生物学分析也为研究衰老提供了新的手段。由于衰老是复杂的生物学过程,影响因素多,只有充分进行比较医学研究才能更好地将研究成果转化,为人类健康老年提供保障。
Aging is an inevitable outcome for all organisms.Researchers are exploring how to delay senescence and reduce the incidences of age-related diseases,prolong life-span and improve the quality of life in old age.Establishing aging animal models that show aging phenotypes similar to those of humans is an effective way to explore the mechanisms of human aging and research of anti-aging drugs.There are various animal models,such as nematodes,rodents and primates.In recent years,different types of genetically modified mice have emerged.At the same time,researchers have started to use animal models with different life-spans to conduct comparative studies.As aging is a complex biological process with many influencing factors,only by conducting fully comparative medical research can we better transform the research results of aging and guarantee healthier aging of human beings.
作者
卢延华
管博文
孟爱民
LU Yanhua;GUAN Bowen;MENG Aimin(Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS),Comparative Medicine Center,Peking Union Medical College(PUMC),NHC Key Laboratory of Human Disease Comparative Medicine,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing 100021,China)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第9期109-113,共5页
Chinese Journal of Comparative Medicine
基金
中国医学科学院医学与健康科技创新工程经费资助(2017-I2M-3-015)
国家重点研发计划(2017YFA0105204)
国家自然科学基金(81573094)。
关键词
衰老
动物模型
比较医学
aging
animal model
comparative medicine
