摘要
目的:探究胃癌组织中miR-451与MIF表达与临床病理之间关系。方法:抽调医院接收的胃癌患者共40例,采用RT-PCR检测方式对患者肿瘤、肿瘤旁组织内的miR-451与MIF水平进行检测,并分析与胃癌临床病理关系。结果:MIF、miR-451的表达与年龄、性别之间差异无统计学意义(P>0.05),与分化程度、侵润深度、淋巴结转移之间差异有统计学意义(P<0.05)。结论:胃癌组织中MIF表达显著升高,而miR-451水平处于下降,两者与胃癌疾病发展具有紧密联系,能够作为临床上诊断疾病辅助指标,对胃癌患者后期治疗、预后具有重要作用。
Objective:To explore the correlation of miR-451 and MIF(recombinant human macrophage migration inhibitor factor)expressions with clinical pathology in the gastric cancer tissues.Methods:40 gastric cancer patients treated in hospital were selected.The RT-PCR(Reverse Transcription-Polymerase Chain Reaction)was used to detect the miR-451 and MIF expressions to analyze its correlation with clinical pathology.Results:The miR-451 and MIF expressions were not correlated with the patient's age and gender(P>0.05);the miR-451 and MIF expressions were correlated with the differentiation degree,infiltration depth and lymphatic metastasis(P<0.05).Conclusion:In the gastric cancer tissues,the MIF expressions are greatly increased while the miR-451 expressions are reduced.The miR-451 and MIF expressions are closely correlated with the disease progression.Thus it can be considered as the auxiliary diagnosis indicators and play a key role in the subsequent treatment and clinical prognosis.
作者
卢运龙
LU Yun-long(Affiliated Hospital Of Youjiang Medical University For Nationalities,Baise 533000,Guangxi)
出处
《安徽卫生职业技术学院学报》
2019年第4期104-105,共2页
Journal of Anhui Health Vocational & Technical College
关键词
胃癌组织
临床病理
肿瘤
检测
Gastric cancer tissues
Clinical pathology
Tumor
Detection
