摘要
目的:探究重组人表皮生长因子凝胶联合多磺酸粘多糖乳膏对面部脂溢性皮炎的疗效,分析治疗安全性。方法:选择符合标准的80例面部脂溢性皮炎患者,随机分为观察组40例,采用重组人表皮生长因子凝胶联合多磺酸粘多糖乳膏治疗,对照组40例仅采用多磺酸粘多糖乳膏治疗,共治疗4周。比较2组的疗效、不良反应发生情况及治疗前后的生活质量及皮肤屏障功能变化情况。结果:观察组的治疗有效率92.50%明显高于对照组的72.50%(P<0.05)。治疗后,2组的表皮水分丢失量、角质层含水量、表皮皮脂含量均有所改善,观察组改善更明显(P<0.05)。治疗后,2组的DLQI得分均有所降低,观察组得分明显低于对照组(P<0.05)。观察组的不良反应发生率7.50%与对照组的5.00%比较无明显差异(P>0.05)。结论:重组人表皮生长因子凝胶联合多磺酸粘多糖乳膏治疗面部脂溢性皮炎,疗效显著,不良反应少,安全可靠,有助于改善皮肤屏障功能,提升生活质量,值得临床推广。
Objective:To explore the effect of recombinant human epidermal growth factor gel combined with polysulfonic acid mucopolysaccharide cream on facial seborrheic dermatitis,and to analyze the safety of treatment.Methods:80 patients with facial seborrheic dermatitis who met the criteria were selected.According to the random number method,40 cases were divided into observation groups.Recombinant human epidermal growth factor gel was combined with polysulfonic acid mucopolysaccharide cream.40 patients in the control group were treated with only polysulfonic acid mucopolysaccharide cream for a total of 4 weeks.The efficacy,adverse reactions,and quality of life and skin barrier function before and after treatment were compared between the two groups.Results:The effective rate of treatment in the observation group was 92.50%,which was significantly higher than that in the control group(72.50%)(P<0.05).After treatment,the water loss of the epidermis,the water content of the stratum corneum,and the sebum content of the epidermis were improved in both groups,and the improvement in the observation group was more obvious(P<0.05).After treatment,the DLQI scores of both groups were reduced,and the scores of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions in the observation group of 7.50%compared with 5.00%in the control group(P>0.05).Conclusion:Recombinant human epidermal growth factor gel combined with polysulfonic acid mucopolysaccharide cream for the treatment of facial seborrheic dermatitis has obvious curative effect,less adverse reactions,safe and reliable,which can improve skin barrier function and improve quality of life.It is worthy of clinical promotion.
作者
李舒
LI Shu(Zhengzhou Seventh People’s Hospital,Henan Zhengzhou 450000,China)
出处
《中医药临床杂志》
2019年第9期1756-1759,共4页
Clinical Journal of Traditional Chinese Medicine
关键词
人表皮生长因子
多磺酸粘多糖
脂溢性皮炎
疗效
Human epidermal growth factor
Polysulfonic acid mucopolysaccharide
Seborrheic dermatitis
Therapeutic effect
