摘要
目的探讨内镜下射频消融术(RFA)辅助基础疗法治疗慢性隆起糜烂型胃炎患者的效果及对胃肠道激素的影响。方法选取武汉科技大学附属孝感医院经胃镜检查确诊的93例慢性隆起糜烂性胃炎患者,采用随机区组设计分为观察组(47例)和对照组(46例)。观察组患者采用内镜下RFA治疗+基础三联疗法(奥美拉唑+阿莫西林+克拉霉素)治疗,对照组患者仅给予基础三联疗法治疗;对比两组的临床疗效、幽门螺杆菌(H.pylori)根除率、血清胃动素、瘦素、胃泌素、血管活性肠肽(VIP)的变化。结果治疗后,观察组的临床疗效显著的优于对照组(P<0.05);观察组的H.pylori根除率为90.48%、对照组为83.72%,两组比较差异无统计学意义(P>0.05)。治疗前,两组的血清胃动素、瘦素、胃泌素、VIP水平比较,差异均无统计学意义(P>0.05);治疗后,观察组的的血清胃泌素、VIP水平显著低于对照组(P均<0.05),观察组的血清胃动素、瘦素水平显著的高于对照组(P均<0.05)。结论内镜下RFA辅助基础疗法治疗慢性隆起糜烂型胃炎患者对于促进糜烂面的愈合具有一定的作用,糜烂面愈合后对于患者胃肠道激素水平的改善也具有一定的作用。
Objective To investigate the effect of endoscopic radiofrequency ablation(RFA)-assisted basic therapy on patients with chronic erosive otitis gastritis and its effects on gastrointestinal hormones.Methods A total of 93 patients with chronic erosive otitis gastritis confirmed by gastroscopy in our hospital were randomly divided into observation group(47 cases and control group).The observation group was treated with endoscopic RFA+basic triple therapy(Ogilvy).Treatment with carbazole+amoxicillin+clarithromycin,the control group was only given basic triple therapy;the efficacy of the two groups,Helicobacter pylori(H.pylori)negative rate,serum motilin,leptin,gastrin,Changes in vasoactive intestinal peptide(VIP).Results After treatment,after endoscopic re-examination,the endoscopic clinical effect of the observation group was significantly better than the control group,the difference was statistically significant(P<0.05);the H.pylori negative rate of the observation group was 90.48%,the control group The negative rate of H.pylori was 83.72%.There was no significant difference between the two groups(P>0.05).Before treatment,the serum motilin,leptin,gastrin and VIP levels in the observation group and the control group were compared.The significance of the study was(P>0.05).After treatment,the serum gastrin and VIP levels in the observation group were significantly lower than those in the control group(P<0.05).The serum motilin and leptin levels in the observation group were significantly higher than those in the control group.The difference was statistically significant(P<0.05).Conclusion Endoscopic RFA-assisted basic therapy for patients with chronic erosive erosive gastritis has a certain effect on promoting the healing of erosion surface.After healing of the erosion surface,it also has a certain effect on the improvement of gastrointestinal hormone levels in patients.
作者
徐凡莉
熊倩
徐志军
XU Fan-li;XIONG Qian;XU Zhi-jun(Xiaogan Hospital affiliated to Wuhan University of Science and Technology,Xiaogan,Hubei 432000;Xiaogan City First People s Hospital,Xiaogan,Hubei 432000;Xiaogan City Maternal and Child Health Hospital,Xiaogan,Hubei 432000)
出处
《现代消化及介入诊疗》
2019年第9期957-960,共4页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
国家自然科学基金(51707076)
关键词
内镜
射频消融术
隆起糜烂型
胃炎
胃肠道激素
Endoscopy
Radiofrequency ablation
Bulging erosive
Gastritis
Gastrointestinal hormone
