摘要
目的:观察替米沙坦联合骨化三醇治疗糖尿病肾病(DN)的应用价值。方法:选取58例DN患者为研究对象,按照随机数字表法分为对照组与观察组各29例。对照组使用替米沙坦进行治疗,观察组在对照组基础上联合骨化三醇治疗。比较两组治疗后的总有效率,治疗前后肾功能指标(血清肌酐、尿蛋白排泄率、24 h尿蛋白量)和血糖水平(糖化血红蛋白、空腹血糖),治疗后炎症因子水平[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]以及两组不良反应发生率。结果:观察组总有效率为93.10%(27/29),明显高于对照组的72.41%(21/29),比较差异有统计学意义(P<0.05);治疗后,观察组各项肾功能指标、血糖水平及各项炎症因子水平均明显优于对照组,差异均有统计学意义(P<0.05)。结论:替米沙坦联合骨化三醇治疗DN的效果优于替米沙坦的效果。
Objective:To analyze values of Telmisartan combined with Calcitriol in treatment of diabetic nephropathy(DN).Methods:58 patients with DN were selected as the study subjects.According to the random number table method,they were divided into control group(n=29)and observation group(n=29).The control group was treated with Telmisartan,while the observation group was treated with Calcitriol on the basis of that of the control group.The total effective rate after the treatment was compared between the two groups.The renal function indexes(serum creatinine,urinary protein excretion rate,24 h urine protein amount)and blood glucose levels(glycated hemoglobin,fasting blood glucose)before and after the treatment,the inflammatory factor levels after the treatment[interleukin-6(IL-6),interleukin-8(IL-8),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.10%(27/29),which was significantly higher than that of the control group(72.41%,21/29),and the difference was statistically significant(P<0.05).After the treatment,the renal function indexes,the blood glucose levels and the levels of various inflammatory factors of the observation group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).Conclusions:Telmisartan combined with calcitriol is more effective in the treatment of diabetic nephropathy than single Telmisartan.
作者
陈东
刘强强
王琳
朱峰
CHEN Dong;LIU Qiangqiang;WANG Lin;ZHU Feng(Dalian University Affiliated Xinhua Hospital,Dalian 116021 Liaoning,China)
出处
《中国民康医学》
2019年第14期13-14,20,共3页
Medical Journal of Chinese People’s Health
关键词
糖尿病
肾病
替米沙坦
骨化三醇
Diabetes mellitus
Nephropathy
Telmisartan
Calcitriol
