摘要
目的探讨从婴儿到青少年期凝血四项指标的动态变化,并建立其不同年龄段的参考范围。方法回顾性分析2016年1月至2018年6月间在贵州医科大学附属医院检查凝血功能的符合研究目的1053例健康不同年龄人群的凝血检测指标,包括活化部分凝血激酶时间(aPTT)、凝血酶原时间(PT)、凝血酶凝时间(TT)及纤维蛋白原(Fbg按年龄分为1-5月、6-12月、1-5岁、6-10岁及11-17岁五个年龄段,并对每个年龄段再按照男、女性别分组。统计分析年龄及性别因素对凝血四项指标的影响,并建立相应的参考范围。结果1-5月组中女性组的Fbg比男性组高(P<0.05),其他各年龄段男性与女性凝血四项指标水平比较差异无统计学意义(P>0.05);在婴儿期(1-12月),PT、aPTT及TT随着年龄的增长而)05-0、TT在1-5 y之后变化无统计学差异,aPTT在6 m之后变化无统计学意义(P>0.05);Fbg在1-5岁时变化显著(P<0.05),而在1-5岁以后比较差异无统计学意义(P>0.05);将年龄合并之后的参考范围:1-5月、6-12月及1-17岁的PT(s)参考范围分别为10.04-16.00、11.06-14.24、10.99-14.99;1-5月及6月-17岁的aPTT(s)参考范围分别为30.43-53.25、29.72-47.68;1-12 m、1-17 y的Fbg(g/L)考范围分别为1.26-4.12、1.61-4.27;1-12 m、1-17 y的TT(s)参考范围分别为15.27-22.45、14.53-21.31。结论从婴儿到青少年期,机体凝血系统随年龄增长发育逐渐完善,出、凝血检测指标的水平呈动态变化,其参考值范围也随之发生相应的改变。建议各临床实验室建立与不同年龄段尤其是婴儿期相适应的凝血试验参考范围,为临床诊疗提供可靠的实验室依据。
Objective To explore the dynamic changes of four indicators of blood coagulation from infants to adolescents and establish the reference range of different age groups.Methods A retrospective analysis was performed on the coagulation function of 1053 healthy people of different ages who were examined in the affiliated hospital of guizhou medical university from January 2016 to June 2018.Including activated partial thrombin time(aPTT),prothrombin time(PT),thrombin coagulation time(TT)and fibrinogen(Fbg);According to different ages,the patients were divided into five groups:1-5 months,6-12 months,1-5 years,6-10 years and 11-17 years.Each group was divided into male and female groups.Statistical analysis of gender and age on the four indicators of coagulation.Results The Fbg level of the female group was higher than that of the male group(P<0.05)in the 1-5 months group,and there was no significant difference in the level of the four coagulation indicators between males and females in other ages(P>0.05).In infancy(1-12 months),PT,aPTT and TT decreased with age.PT and TT showed no statistical difference after 1-5 y,and aPTT showed no statistical difference after 6 m(P>0.05).The change of FIB was significant at the age of 1-5 years(P<0.05),while the difference was not statistically significant after the age of 1-5 years(P>0.05).The reference ranges after age combination:PT(s)reference ranges of 1-5 m,6-12 m and 1-17 y are respectively 10.04-16.00,11.06-14.24 and 10.99-14.99.aPTT(s)reference ranges of 1-5 m and 6 m-17 y were 30.43-53.25 and 29.72-47.68 respectively.The Fbg(g/L)reference ranges of 1-12 m and 1-17 y were 1.26-4.12 and 1.61-4.27 respectively.TT(s)reference ranges of 1-12 m and 1-17 y were 15.27-22.45 and 14.53-21.31,respectively.Conclusion From infancy to adolescence,the blood coagulation system of the body gradually improves with the growth of age,and the reference range of blood coagulation detection indicators also changes accordingly.Each clinical laboratory should establish the reference range of coagulation test suitable for different age groups,especially for infants,so as to provide reliable laboratory basis for clinical diagnosis and treatment.
作者
徐殿琴
袁婷
谭玉洁
XU Dian-qin;YUAN Ting;TAN Yu-jie(Department of Clinical Laboratory,Guizhou Medical University,Guiyang 550025,Guizhou,China;Department of Clinical Laboratory,Affiliated hospital of Guizhou Medical University,Guiyang 550025,Guizhou,China)
出处
《血栓与止血学》
2019年第5期725-728,共4页
Chinese Journal of Thrombosis and Hemostasis
