摘要
目的探讨原发结直肠腺癌^18F-FDG PET/CT代谢参数与临床病理因素的关系。方法回顾性分析经手术病理证实的52例结直肠腺癌患者的^18F-FDG PET/CT显像特征和临床资料,记录肿瘤原发灶最大径、最大标准摄取值(SUV max)、平均标准摄取值(SUV mean)及代谢体积(MTV),并计算病灶糖酵解总量(TLG)。按肿瘤原发灶最大径、T分期、N分期及细胞组织分化程度分别进行分组,比较组间上述参数的差异,分析其与临床病理特征的相关性。结果52例结直肠腺癌原发灶的SUV max、SUV mean、MTV及TLG分别为13.38±7.34、7.75±3.94、(15.83±11.18)cm 3及103.15(45.28,140.23)g。不同原发灶最大径组间各代谢参数差异均有统计学意义(P均<0.05);不同T分期组间肿瘤原发灶SUV max、SUV mean差异均无统计学意义(P均>0.05),MTV、TLG差异有统计学意义(P均<0.05);不同N分期、细胞组织分化程度组间肿瘤原发灶各代谢参数差异均无统计学意义(P均>0.05)。SUV max、SUV mean与原发灶最大径呈正相关(P均<0.05),与T分期、N分期、细胞组织分化程度均无明显相关(P均>0.05);MTV、TLG与原发灶最大径、T分期呈正相关(P均<0.05),与N分期和组织分化程度无明显相关(P均>0.05)。结论结直肠腺癌的体积参数MTV、TLG可在一定程度上反映病理因素,较SUV max、SUV mean的评价价值更高。
Objective To investigate the correlation of ^18F-FDG PET/CT imaging metabolic indexes and clinicopathological factors of primary colorectal adenocarcinoma.Methods Clinical data of 52 patients with colorectal adenocarcinoma confirmed by operation and pathology were retrospectively analyzed.All patients underwent ^18F-FDG PET/CT imaging,and the maximum diameter,maximum standard uptake value(SUV max),mean standard uptake value(SUV mean)and metabolic volume(MTV)of the primary tumors were recorded,and the total lesion glycolysis(TLG)was calculated.The patients were grouped according to the largest diameter,T stage,N stage and cell differentiation degree of the primary tumor respectively,and the differences of the above parameters were compared,and the correlations of the above parameters and clinicopathological features were analyzed.Results SUV max,SUV mean,MTV and TLG of 52 patients with colorectal adenocarcinoma were 13.38±7.34,7.75±3.94,(15.83±11.18)cm 3 and 103.15(45.28,140.23)g,respectively.There were significant differences in metabolic indexes of the maximum diameter groups(all P<0.05).There was no significant difference in SUV max and SUV mean among different T-stage groups(both P>0.05),while there were significant differences in MTV and TLG among different T-stage groups(both P<0.05).There was no significant difference in the metabolic indexes of colorectal adenocarcinoma among different N stages and cell differentiation groups(all P>0.05).There were positive correlations of SUV max,SUV mean with the maximum diameter of the primary tumor(both P<0.05),while there was no obvious correlation with T stage,N stage and cell differentiation degrees(all P>0.05).MTV and TLG were positively correlated with the maximum diameter and T stage of the primary tumor(all P<0.05),but not correlated with N stage nor cell differentiation degrees(all P>0.05).Conclusion MTV and TLG can reflect the pathological factors of colorectal adenocarcinoma in some degree,and have higher evaluation value than SUV max and SUV mean.
作者
周锦
张漫雪
徐阳
汤泊
徐亚平
ZHOU Jin;ZHANG Manxue;XU Yang;TANG Bo;XU Yaping(PET/CT Center,Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine,Suqian 223600,China;Department of Nuclear Medicine,Xuzhou Central Hospital,Xuzhou 221009,China)
出处
《中国医学影像技术》
CSCD
北大核心
2019年第10期1517-1521,共5页
Chinese Journal of Medical Imaging Technology
