摘要
促红细胞生成素(EPO)是一种多效性生长因子,对许多细胞和组织具有生长刺激和保护作用。在临床上被广泛应用于治疗各种贫血。近年来研究发现,EPO不仅具有促进骨髓造血功能,在心脏、肾脏、肝脏、脑及视网膜等非造血器官及组织中发挥作用,同时对神经系统亦具有重要的保护作用。
Erythropoietin(EPO)is a multipotent growth factor,which can stimulate and protect many cells and tissues.It is widely used in clinical treatment of various anemia,including renal anemia and tumor-related anemia.It has been found that EPO not only promotes bone marrow hematopoietic function,but also plays an important role in non-hematopoietic organs and tissues such as heart,kidney,liver,brain and retina,as well as in the protection of nervous system.In recent years,there have been many studies and reports about EPO on various systems,but the specific mechanism of EPO has not yet been clearly defined.In this paper,the biological characteristics,physiological functions and the mechanism of action of EPO on various important systems are reviewed.
作者
于秀燕
马宝新
李跃荣
YU Xiu-yan;MA Bao-xin;LI Yue-rong(Department of Cardiology,Affiliated Hospital of Binzhou Medical College,Shandong Binzhou 256600,China)
出处
《海南医学院学报》
CAS
2019年第19期1516-1520,共5页
Journal of Hainan Medical University
基金
山东省医药卫生科技计划项目(2016WS0049)~~
