摘要
目的探讨榄香烯口服乳联合多西他赛和奥沙利铂治疗晚期食管鳞癌的临床疗效。方法选取天津医科大学总医院晚期食管鳞癌患者44例作为研究对象。随机分为观察组(21例,榄香烯口服乳联合多西他赛和奥沙利铂方案)和对照组(23例,多西他赛联合奥沙利铂方案),21 d为1个化疗周期。2个周期后行疗效、生活质量、体重、毒副作用和免疫功能的评价。结果观察组和对照组总有效率、疾病控制率比较,差异无统计学意义(P>0.05);观察组化疗前后Karnofsky评分比较差异有统计学意义(P<0.05);对照组化疗前后的Karnofsky评分比较差异无统计学意义(P>0.05);观察组生活质量提高的人数高于对照组(P<0.05);观察组和对照组化疗前后的体重比较差异无统计学意义(P>0.05);观察组体重增加的人数高于对照组(P<0.05);化疗后观察组WBC减少、PLT减少、ALT升高、胃肠道反应等优于对照组(P <0.05);化疗后观察组和对照组NK细胞活性变化比较差异有统计学意义(P <0.05);CD4^+/CD8^+比值变化比较差异有统计学意义(P <0.05)。结论榄香烯口服乳联合多西他赛和奥沙利铂治疗晚期食管鳞癌患者,可改善其生活质量,增加体重,且安全性好,无严重不良反应。
Objective To study clinical effect of elemene oral emulsion combined with docetaxel and oxaliplatin in treatment of patients with advanced esophageal squamous cancer.Methods Totally 44 cases with advanced esophageal squamous cancer were selected as the objects of the study and divided into observation group(n=21,elemene oral emulsion combined with docetaxel and oxaliplatin)and control group(n=23,docetaxel and oxaliplatin),and 21 days was a chemotherapy cycle.Effect,living quality,weight,toxocity and immunity of advanced esophageal squamous cancer were made comments after 2 cycles.Results There was no significant difference in total effective rate and disease control rate between two groups(P>0.05).The difference of Karnofsky performance score before and after chemotherapy in the observation group was statistically significant(P<0.05),but the control group was the opposite(P>0.05).The living quality of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The weight difference between the observation and the control group before and after chemotherapy was not statistically significant(P>0.05).Patients gaining weight of the observation group was more than that of the control group,and the difference was statistically significant(P<0.05).The observation group was superior to the control group in WBC reduction,PLT reduction,ALT elevation and gastrointestinal reaction after chemotherapy,and the difference of two groups was statistically significant (P < 0.05). The changes of NK cell activity in the observation group and the control group after chemotherapy werestatistically significant (P < 0.05);the difference of ratio of CD4+ and CD8+ was statistically significant (P < 0.05).Conclusions Elemene oral emulsion combined with docetaxel and oxaliplatin can improve the living qualityand increase the weight of patients with advanced esophageal squamous cancer, with good safety and no seriousadverse side effect.
作者
石岩
王琦
郑锴
Yan Shi;Qi Wang;Kai Zheng(Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《中国现代医学杂志》
CAS
2019年第19期88-92,共5页
China Journal of Modern Medicine
关键词
食管鳞癌
榄香烯口服乳
多西他赛
奥沙利铂
esophageal neoplasms
elemene oral emulsion
docetaxel
oxaliplatin
