摘要
目的探讨原发性肝癌(PLC)患者血清甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、肿瘤特异性生长因子(TSGF)、高尔基体蛋白73(GP73)水平变化及其电子计算机断层扫描(CT)特征,分析总结其临床诊断价值。方法选取2017年3月至2019年3月铜川市妇幼保健院接诊的62例PLC患者为研究组,选取我院同期接诊的31例肝脏良性病变患者为对照A组,31例健康者为对照B组。患者入院后,检测并比较三组受检者血清AFP、AFU、TSGF、GP73的水平及其CT特征。结果研究组患者的血清AFP、AFU、TSGF、GP73水平[(335.92±68.44)μg/L、(71.26±12.02)U/L、(75.23±16.51)U/mL、(221.31±47.33)μg/L]明显高于对照A组[(53.24±12.67)μg/L、(42.14±9.46)U/L、(52.88±11.19)U/mL、(139.28±35.15)μg/L]和对照B组[(6.90±3.88)μg/L、(25.12±8.38)U/L、(38.14±8.30)U/mL、(67.58±19.74)μg/L],对照A组患者的血清AFP、AFU、TSGF、GP73水平又明显高于对照B组,差异均有统计学意义(P<0.05);研究组患者的血清AFP、AFU、TSGF、GP73检测阳性率分别为61.29%、72.58%、64.52%、75.81%,明显高于对照A组的16.13%、22.58%、29.03%、35.48%和对照B组的6.45%、9.68%、12.90%、16.13%,对照A组患者的血清AFP、AFU、TSGF、GP73检测阳性率又明显高于对照B组,差异均有统计学意义(P<0.05);CT、血清AFP、AFU、TSGF、GP73检测的灵敏度分别为76.12%、64.83%、73.21%、64.35%、82.52%,特异度为93.29%、76.42%、77.68%、82.41%、84.80%,准确度为89.30%、72.13%、76.01%、72.84%、82.73%,CT联合四项指标检测的灵敏度、特异度、准确度分别为97.79%、98.70%、98.50%,明显高于单独检测,差异均有统计学意义(P<0.05)。结论血清AFP、AFU、TSGF、GP73检测水平及CT扫描对PLC患者有一定诊断价值,联合检测可以有效提高诊断准确度。
Objective To investigate the changes of serum alpha-fetoprotein(AFP), α-L-fucosidase(AFU), tumor specific growth factor(TSGF) and Golgi protein 73(GP73) in patients with primary liver cancer and their computed tomography(CT) features, analysis and summarize their clinical diagnostic value. Methods A total of 62 cases patients with primary liver cancer, who admitted to Tongchuan Maternal and Child Health Hospital from March 2017 to March 2019, were selected as the study group. At the same time, 31 patients with benign liver disease who admitted to our hospital were selected as the control group A and 31 healthy subjects were chosen as the control group B. After admission, the levels of serum AFP, AFU, TSGF and GP73 and their CT features in the three groups were compared. Results The serum levels of AFP, AFU, TSGF, and GP73 in the study group were(335.92±68.44) μg/L,(71.26±12.02) U/L,(75.23±16.51) U/mL,(221.31±47.33) μg/L, respectively, which were significantly higher than corresponding(53.24 ± 12.67) μ g/L,(42.14 ± 9.46) U/L,(52.88 ± 11.19) U/mL,(139.28 ± 35.15) μ g/L in the control group A and corresponding(6.90±3.88) μg/L,(25.12±8.38) U/L,(38.14±8.30) U/mL,(67.58±19.74) μg/L in the control group B;while the levels of serum AFP, AFU, TSGF and GP73 in the control group A were significantly higher than those in the control group B(all P<0.05). The positive rates of serum AFP, AFU, TSGF and GP73 in the study group were 61.29%, 72.58%, 64.52% and 75.81%, respectively, which were significantly higher than corresponding 16.13%,22.58%, 29.03%, 35.48% in the control group A and corresponding 6.45%, 9.68%, 12.90%, 16.13% in the control group B;while the positive rates of serum AFP, AFU, TSGF and GP73 in the control group A were significantly higher than those in the control group B(all P<0.05). The sensitivity of CT, serum AFP, AFU, TSGF, GP73 detection were 76.12%,64.83%, 73.21%, 64.35%, 82.52%, respectively;the specificity were 93.29%, 76.42%, 77.68%, 82.41%, 84.80%;the accuracy were 89.30%, 72.13%, 76.01%, 72.84%, 82.73%;the sensitivity, specificity, and accuracy of CT combined with the four indicators were 97.79%, 98.70%, 98.50%, respectively, which were significantly higher than the single detection(all P<0.05). Conclusion Serum AFP, AFU, TSGF, GP73 detection level and CT scan have certain diagnostic value for patients with primary liver cancer. The combined detection can effectively improve the diagnostic accuracy.
作者
黎小花
王群拴
刘阿静
邢娟
LI Xiao-hua;WANG Qun-tie;LIU A-jing;XING Juan(Department Clinical Laboratory,Tongchuan Maternal and Child Health Hospital,Gongchuan 727007,Shaanxi,CHINA;Department of Imaging,Tongchuan People's Hospital,Gongchuan 727000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第19期2473-2475,共3页
Hainan Medical Journal
