摘要
目的评价不同剂量右美托咪定治疗老年骨盆骨折术后寒战的效果。方法选择2016年5月至2017年11月北京积水潭医院重症医学科收治的老年骨盆骨折术后病人100例(寒战分级3~4级),采用随机数字表法,将其分为4组,分别为对照组(C组)、D1、D2和D3组,每组25例。病人发生寒战后,C组输注生理盐水50 mL,输注速率为5 mL/min,D1、D2和D3组静脉输注右美托咪定0.1、0.3和0.5μg/kg(溶于50 mL生理盐水中)。记录4组寒战停止时间、有效率,并观察干预前(T1)、干预后5 min(T2)、干预后20 min(T3)平均动脉压(MAP)及心率的变化和不良反应发生情况。结果D2、D3组的寒战停止时间均较D1及C组短,有效率较D1及C组高(P<0.05);D2组与D3组之间差异无统计学意义(P>0.05)。D3组T2、T3时点MAP及心率低于C组及D1、D2组,差异均有统计学意义(P<0.05)。4组均无不良反应发生。结论右美托咪定0.3μg/kg可以有效治疗老年骨盆骨折术后寒战,同时对血流动力学的影响较小。
Objective To evaluate the efficacy of different doses of dexmedetomidine in treating postoperative shivering in the elderly with pelvic fracture.Methods One hundred elderly patients with pelvic fracture who developed postoperative shivering were randomly divided into control group(group C)and dexmedetomidine 0.1,0.3 and 0.5μg/kg groups(group D1,D2 and D3)(n=25)using a random number table.In group D1,D2 and D3,0.1,0.3 and 0.5μg/kg dexmedetomidine(in 50 mL normal saline)were infused intravenously,respectively.In group C,50 mL normal saline was infused at a rate of 5 mL/min.Shivering stopping time,effective rate,mean arterial pressure(MAP),heart rate and adverse reactions were recorded and compared among the four groups.Results Lower shivering cessation time(P<0.05)and higher response rate(P<0.05)were observed in group D2 and group D3 compared with group D1 and group C.The levels of MAP and heart rate in group D3 at T2,T3 was statistically lower than that in group C,D1 and D2(P<0.05).No adverse reactions were observed in the four groups.Conclusions 0.3μg/kg dexmedetomidine is effective in treating postoperative shivering in the elderly with pelvic fracture and shows less influence on hemodynamics.
作者
牛思萌
周宁
白颖
NIU Si-meng;ZHOU Ning;BAI Ying(Intensive Care Unit,Ji Shui Tan Hospital and Fourth Medical College of Peking University,Beijing 100035,China)
出处
《实用老年医学》
CAS
2019年第10期1016-1018,1021,共4页
Practical Geriatrics
关键词
右美托咪定
寒战
老年
骨盆骨折
dexmedetomidine
shivering
aged
pelvic fracture
