摘要
目的:观察毓麟珠汤联合他莫昔芬治疗多囊卵巢综合征(PCOS)的疗效,并探讨其对血脂和脂肪因子的影响。方法:选择符合纳入标准的PCOS患者104例,根据随机数表法将患者分为观察组和对照组,各52例。对照组给予他莫昔芬治疗,观察组在对照组的基础上给予毓麟珠汤治疗。观察两组患者临床疗效,治疗前后腰围/臀围、中医症候积分、卵巢体积、卵泡数、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、雌二醇(E 2)、睾酮(T)、黄体生成激素(LH)、卵泡生成激素(FSH)、丝氨酸蛋白酶抑制剂(Vaspin)、内脂素(Visfatin)、脂联素(Leptin)和瘦素(Apelin)水平的变化。结果:观察组的总有效率为88.46%(46/52)明显高于对照组的69.23%(36/52),观察组的临床疗效优于对照组(χ^2=4.670,P<0.05)。两组治疗前腰围/臀围、中医症候积分、卵巢体积、卵泡数、TC、TG、LDL-C、HDL-C、Vaspin、Visfatin、Leptin和Apelin水平比较无统计学意义(P>0.05),且有可比性;治疗后两组患者腰围/臀围、中医症候积分、卵巢体积、卵泡数、TC、LDL-C、T、LH、FSH、Vaspin、Visfatin和Apelin水平较治疗前明显降低(P<0.01),而两组患者的E 2和Leptin较治疗前明显升高(P<0.01),且治疗后观察组优于对照组(P<0.01)。结论:毓麟珠汤联合他莫昔芬治疗PCOS疗效显著,可能与毓麟珠汤降低机体血脂水平,纠正机体激素和脂肪因子紊乱有关。
Objective:To observe the efficacy of Yulinzhu Decoction combined with Tamoxifen in the treatment of polycystic ovary syndrome(PCOS)and its impact on blood lipids and adipocytokines.Methods:104 PCOS patients were randomly divided into the observation group and the control group,with 52 cases in each group.The control group was treated with Tamoxifen;on which basis,the observation group was also treated with Yulinzhu Decoction.The efficacy was observed in the two groups;the waist circumference/hip circumference,TCM syndrome score,ovarian volume,follicle number,the levels of TC,TG,LDL-C,HDL-C,Vaspin,Visfatin,Leptin and Apelin were also observed in the two groups after the treatment.Results:The total effective rate was 88.46%(46/52)in the observation group,which was significantly higher than 69.23%(36/52)in the control group(χ^2=4.670,P<0.05).There were no significant differences in the levels of waist circumference/hip circumference,TCM syndrome score,ovarian volume,follicle number,TC,TG,LDL-C,HDL-C,Vaspin,Visfatin,Leptin and Apelin between the two groups before the treatment(P>0.05).After the treatment,the levels of waist circumference/hip circumference,TCM syndrome score,ovarian volume,follicle number,TC,LDL-C,T,LH,FSH,Vaspin,Visfatin and Apelin were significantly lowered than those before the treatment in the two groups(P<0.01);whereas the levels of E 2 and Leptin were significantly increased in the two groups after the treatment than those before the treatment(P<0.01);of which the increases and decreases were more significant in the observation group than those in the control group(P<0.01).Conclusion:Yulinzhu Decoction combined with Tamoxifen is effective in the treatment of PCOS.The mechanism may be related to reducing blood lipid levels and correcting the disorders of body hormones and Adipocytokines.
作者
李虹
LI Hong(The Seventh People's Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)
出处
《中医药信息》
2019年第5期92-96,共5页
Information on Traditional Chinese Medicine
关键词
毓麟珠汤
他莫昔芬
多囊卵巢综合征
血脂
脂肪因子
Yulinzhu Decoction
Tamoxifen
Polycystic ovary syndrome
Blood lipids
Adipocytokines
