摘要
目的探讨慢性肾炎采用阿托伐他汀联合缬沙坦治疗的疗效以及安全性。方法将2016年12月-2018年5月期间来本院就诊的100例慢性肾炎患者进行分组研究,就缬沙坦治疗(对照组,n=50)与阿托伐他汀联合缬沙坦治疗(观察组,n=50)对肾功能指标、血压水平以及不良反应发生率进行比较分析。结果观察组24 h尿蛋白量为(1.07±0.44)g、血清肌酐为(98.36±9.12)μmol/L、尿素氮为(6.55±0.81)mmol/L、肾小球率过滤为(1.01±0.31)mg/L、收缩压为(120.86±3.22)mmHg,舒张压为(71.33±2.14)mmHg,不良反应发生率为4.0%,均相对于对照组较低,P<0.05。结论慢性肾炎采用阿托伐他汀联合缬沙坦治疗的疗效显著,可有效稳定血压,改善肾功能指标,降低不良反应发生率。
Objective To investigate the efficacy and safety of atorvastatin combined with valsartan in chronic nephritis.Methods A group of 100 patients with chronic nephritis who came to our hospital from December 2016 to May 2018 were enrolled in a group study on valsartan(control group,n=50)and atorvastatin combined with valsartan.(Observation group,n=50)Comparative analysis of renal function indicators,blood pressure levels,and incidence of adverse reactions.Results The amount of urinary protein in the observation group was(1.07±0.44)g,serum creatinine was(98.36±9.12)μmol/L,urea nitrogen was(6.55±0.81)mmol/L,and glomerular rate was(1.01±0.31)mg/L,systolic blood pressure was(120.86±3.22)mmHg,diastolic blood pressure was(71.33±2.14)mmHg,and adverse reaction rate was 4.0%,which was lower than that of the control group,P<0.05.Conclusion The treatment of chronic nephritis with atorvastatin combined with valsartan is effective,can effectively stabilize blood pressure,improve renal function indicators,and reduce the incidence of adverse reactions.
作者
陆树连
罗国平
胡彦维
LU Shulian;LUO Guoping;HU Yanwei(Department of Nephrology,Shiyan People's Hospital,Bao'an District,Shenzhen Guangdong 518100,China;Department of Nephrology,Qingcheng People's Hospital,Qingyuan Guangdong 511500,China)
出处
《中国卫生标准管理》
2019年第20期85-87,共3页
China Health Standard Management
关键词
慢性肾炎
阿托伐他汀
缬沙坦
疗效
安全性
不良反应
chronic nephritis
atorvastatin
valsartan
efficacy
safety
adverse reactions
