摘要
目的系统评价以黄芪为主的中成药或方剂对气虚型便秘的疗效及安全性。方法计算机检索1989年1月-2017年6月Cochrane图书馆临床试验注册库、Medline、Embase、Pubmed、中国知网(CNKI)、中国生物医学文献数据库(CBM)、重庆维普数据库(VIP),纳入以黄芪为主的药或方剂与西药、中药、健康教育对照,以及以黄芪为主的药或方剂联合西药与以西药为对照组治疗气虚型便秘的临床试验研究,按照Cochrane Handbook 5.1.0标准,由两位研究者对符合纳入标准的试验数据进行独立筛选、质量评价以及原始资料提取并交叉核对,Meta分析采用RevMan 5.3软件完成。结果共纳入26个研究,包括1955例患者。大部分研究方法学质量较低且样本含量小。Meta分析结果显示:黄芪能改善气虚型功能性便秘患者的症状及结肠传输功能,其疗效优于部分西药[痊愈率:RR=1.87,95%CI(1.62,2.16);总体有效率:RR=1.32,95%CI(1.25,1.39)]及部分中药[痊愈率:RR=1.42,95%CI(1.08,1.89);总体有效率:RR=1.23,95%CI(1.11,1.37)];黄芪联合西药疗效优于单纯应用西药[痊愈率:RR=1.52,95%CI(1.13,2.06);总体有效率:RR=1.18,95%CI(1.08,1.28)]。结论以黄芪为主的中成药或方剂治疗气虚型功能性便秘安全有效,但因尚缺乏高质量的研究,目前还不能得到较为可靠的结论。
Objective To assess the benefits and safety of prescription with astragalus membranaceus for functional constipation(FC)with qi deficiency type.Method The Cochrane Library clinical trials registry,Medline,Embase,pubmed,CNKI,CMB,VIP database were searched from January 1989 to June 2017,and the term included in the experiment of Astragalus based medicine or prescription and Western medicine,traditional Chinese medicine,health education,as well as astragalus membranaceus based medicine or prescription combined with western medicine and western medicine as the control group.According to the Cochrane Handbook 5.1.0 standard,two researchers conducted independent screening,quality evaluation,and raw data extraction and cross-checking of the test data that met the inclusion criteria.The meta-analysis was performed using RevMan 5.3 software.Results 26 trials involving 1955 people were included.Most of the trials had low methodology quality and small sample.Meta-analysis results showed that astragalus membranaceus could improve the symptoms and colonic transit function with qi deficiency type,and the curative effect was better than that of some western medicines[cure rate:RR=1.87,95%CI(1.62,2.16);the total efficiency:RR=1.32,95%CI(1.25,1.39)]and part of the traditional Chinese medicine[cure rate:RR=1.42,95%CI(1.08,1.89);the total efficiency:RR=1.23,95%CI(1.11,1.37)].The curative effect on astragalus membranaceus and western medicine was better than the simple application of Western Medicine[cure rate:RR=1.52,95%CI(1.13,2.06);the total efficiency:RR=1.18,95%CI(1.08,1.28)].Conclusions The traditional Chinese medicine or prescription based on astragalus membranaceus is safe and effective in the treatment of functional constipation with qi deficiency type.However,it is still unable to obtain more reliable conclusions due to lack of high quality research.
作者
余克强
伍静
龚翰林
何洪波
杨春梅
YU Ke-qiang;WU jing;GONG Han-lin;HE Hong-bo;YANG Chun-mei(Department of Integrated Chinese and Western Medicine,Cheng Du Shang Jin Nan Fu Hospital/West China Hospital of Sichuan University,Chengdu Sichuan 611743;Department of Integrated Chinese and Western Medicine,West China Hospital of Sichuan University,Chengdu Sichuan 610041)
出处
《世界中西医结合杂志》
2019年第10期1360-1367,共8页
World Journal of Integrated Traditional and Western Medicine
基金
四川省科技厅支撑项目(2015SZ0134)
关键词
黄芪
功能性便秘
气虚证
系统评价
Astragalus Membranaceus
Functional Constipation
Qi Deficiency Syndrome
Systematic Review
