摘要
目的探讨抗精神病药物单用与联用对首次复发精神分裂症患者持续用药时间的影响及停药原因。方法选取医院2015年3月至2018年3月收治的患者120例,按随机数字表法分为联合组和单药组,各60例。单药组患者单用第1代或第2代抗精神病药物治疗,联合组从中至少选2种药物联合治疗。结果联合组持续用药时间为(52.06±20.07)周,显著长于单药组的(39.17±12.44)周(P<0.05);两组患者因病耻感、经济原因、缺乏药物相关知识、就医方便度而停药人数占比比较无显著差异(P>0.05),但联合组患者因药品不良反应(ADR)停药的人数占比明显低于单药组(P<0.05);联合组ADR发生率为21.67%,显著低于单药组的41.67%(P<0.05)。结论抗精神病药物单用时持续用药时间显著短于联合用药,且ADR发生风险更高;ADR是导致单一用药患者停药的主要原因。
Objective To investigate the effect of single and combined medication of antipsychotic drugs on duration of medication in patients with the first relapse of schizophrenia and the reasons of drug withdrawal.Methods Totally 120 patients with first relapse schizophrenia admitted to our hospital from March 2015 to March 2018 were selected and divided into the combined medication group and single medication group according to the random number table method,60 cases in each group.The patients in the single medication group were treated with either the first-generation antipsychotic drugs or the second-generation antipsychotic drugs alone,while those in the combined medication group were treated with at least two drugs.Results The duration of continuous medication in the combined medication group was(52.06±20.07)weeks,which was significantly longer than(39.17±12.44)weeks in the single medication group(P<0.05).There was no significant difference between the two groups in the proportion of drug withdrawal due to stigma,economic reason,lack of drug-related knowledge and convenience to medical treatment(P>0.05).However,the proportion of drug withdrawal due to adverse drug reaction(ADR)in the combined medication group was significantly lower than that in the single medication group(P<0.05).The incidence of ADR in the combined medication group was 21.67%,which was significantly lower than 41.67%in the single medication group(P<0.05).Conclusion Compared with those in the combined medication group,the single medication of antipsychotic drugs can effectively shorten the duration of medication in patients with the first relapse of schizophrenia,and the risk of ADR induced by single medication is higher.ADR is the main reason for drug withdrawal in patients treated with single medication.
作者
戴晓燕
桂格莉
DAI Xiaoyan;GUI Geli(Wuhan Mental Health Center,Wuhan,Hubei,China 430000)
出处
《中国药业》
CAS
2019年第22期77-79,共3页
China Pharmaceuticals
基金
湖北省卫生和计划生育委员会科研项目[WJ2015Z0004]
关键词
精神分裂症
持续用药时间
联合用药
药品不良反应
抗精神病药物
合理用药
schizophrenia
duration of medication
combined medication
adverse drug reactions
antipsychotic drugs
rational drug use
