摘要
目的探讨右美托咪定复合舒芬太尼对妇科恶性肿瘤患者术后镇痛及细胞免疫功能的影响。方法选取2015年12月-2018年6月在本院行手术治疗的162例妇科恶性肿瘤患者,其中对照组(81例)给予舒芬太尼,观察组(81例)给予右美托咪定复合舒芬太尼。比较2组患者视觉模拟评分(VAS)、Ramsay评分、细胞免疫功能指标及不良反应的发生情况。结果观察组术后4h、8h、24h及48h的VAS评分均低于对照组,而各时间点的Ramsay评分均高于对照组(P<0.05)。观察组术后24h、48h的CD3^+和CD4^+T淋巴细胞、CD4^+/CD8^+比值以及NK细胞水平均高于对照组(P<0.05)。2组患者术后48h内呼吸抑制、心动过缓的发生率差异无统计学意义(P>0.05),但观察组术后48h内寒战、恶心呕吐和不良反应总发生率均低于对照组,上述差异均有统计学意义(P<0.05)。结论妇科恶性肿瘤患者术后应用右美托咪定复合舒芬太尼具有良好的镇痛镇静效果,可促进患者术后免疫功能恢复。
Objective To investigate the analgesic effect of dexmedetomidine combined with sufentanil on postoperative patient-controlled intravenous analgesia(PCIA)in patients with gynecological malignancies and its effect on cellular immune function.Methods One hundred and sixty two cases of gynecologic malignancies treated in our hospital from Dec.2015 to Jun.2018 were selected.Sufentanil was given to the control group(n=81)and dexmedetomidine combined with sufentanil was given to the observation group(n=81).Visual analogue scale(VAS),Ramsay score,cellular immune function and adverse reactions were compared between the two groups.Results The VAS scores in the observation group at 4 h,8 h,24 h and 48 h after operation was significantly lower than those in the control group,while the Ramsay scores at each time point were higher than those in the control group(P<0.05).The levels of CD3^+ and CD4^+T lymphocyte,CD4^+/CD8^+ ratio and NK cell in observation group were higher than those in control group at 24h and 48h after operation(P<0.05).There was no statistical significance on the difference in the incidence of respiratory depression and bradycardia between the two groups within 48h after operation(P>0.05).The total incidence of shivering,nausea,vomiting and adverse reactions within 48h after operation in the observation group was lower than that in the control group,with the differences statistically significant(P<0.05).Conclusion Dexmedetomidine combined with sufentanil on PCIA has good analgesic and sedative effects in patients with gynecological malignancies.It can promote the recovery of immune function.
作者
罗善红
LUO Shan-hong(Department of Anesthesiology,Huzhou Central Hospital,Huzhou,Zhejiang 313000,China)
出处
《中国卫生检验杂志》
CAS
2019年第20期2494-2497,共4页
Chinese Journal of Health Laboratory Technology
关键词
妇科恶性肿瘤
右美托咪定
舒芬太尼
镇痛
免疫
Gynecological malignancies
Dexmedetomidine
Sufentanil
Analgesia
Immunity
