摘要
目的总结近年氨甲环酸(tranexamic acid,TXA)在创伤骨科手术中应用的研究进展。方法查阅近年来国内外相关文献,对TXA在创伤骨科手术中的应用情况进行总结,并评价其效果。结果TXA在创伤骨科手术中的应用逐渐增多。在髋部骨折手术中静脉或局部应用TXA均可取得良好的血液保护效果,且不增加血栓事件的风险;在骨盆、髋臼骨折等其他创伤骨科大手术中的应用效果仍不明确。结论创伤骨科手术中TXA应用的有效性和安全性仍需要更多研究证实。
Objective To summarize the research progress on the application of tranexamic acid(TXA)in traumatic orthopedic surgery in recent years.Methods The domestic and foreign literature in recent years was reviewed,and the efficacy and safety of TXA in traumatic orthopedic surgeries with different regimen,dose and route of administration were comprehensively summarized and compared.Results The application of TXA in traumatic orthopedic surgeries increased gradually in recent years.Intravenous or topical administration of TXA efficaciously reduced blood loss and transfusion requirements during hip fracture surgery without significantly increasing the risk of thromboembolic events.However,the efficacy was not clear in other traumatic orthopedic surgeries such as pelvic and acetabular fractures.Conclusion More studies are needed to confirm the efficacy and safety of TXA in traumatic orthopedic surgeries.
作者
张少云
肖聪
裴福兴
ZHANG Shaoyun;XIAO Cong;PEI Fuxing(Department of Orthopedics,the Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang Sichuan,621000,P.R.China;Department of Orthopaedics,West China Hospital,Sichuan University,Chengdu Sichuan,610041,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2019年第11期1457-1461,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
绵阳市卫生和计划生育委员会科研课题（201812）~~
关键词
氨甲环酸
创伤骨科手术
髋部骨折
Tranexamic acid
traumatic orthopedic surgery
hip fracture
