摘要
睾丸是一种自然缺氧器官,支持细胞糖酵解产生的乳酸是睾丸中生精细胞的重要能量来源,可快速提供ATP,以满足快速增殖的生精细胞对于能量和物质的需求,正常精子发生过程中能量代谢及调控机制的研究受到了广泛关注。因此,阐明不同因素或者疾病状态下调控支持细胞葡萄糖转运蛋白对葡萄糖的转运过程;乳酸脱氢酶将丙酮酸催化为乳酸的过程;单羧酸转运蛋白对乳酸的转运过程,对保证精子发生和雄性生殖功能的正常进行起着至关重要的作用。本文总结了不同生理状态下精子发生过程中能量代谢供求关系及其变化规律,并深入阐述了内分泌因素、信号通路、miRNA和蛋白质乙酰化修饰在调控细胞糖酵解进程中的作用机制,为后续深入阐明精子发生的分子机制和临床诊疗提供重要参考。
Testis has been reported to be a naturally oxygen-deprived organ. Lactate produced by glycolysis of Sertoli cells is an important source of energy in spermatogenic cells, which quickly provides adenosine triphosphate to meet the needs of rapidly proliferating spermatogenic cells for energy and substances. Wide attention has been drawn to the studies of energy metabolism and its regulatory mechanisms in normal spermatogenesis. It is essential to illuminate the regulation of glucose transport by glucose transporters in Sertoli cells, the catalysis of pyruvate to lactic acid by lactate dehydrogenase and the transport process of the single carboxylate transporter to lactic acid under the influence of different factors or diseases, which play important roles in ensuring the normal spermatogenesis and male reproductive function. This review summarizes the changes of energy metabolism in spermatogenesis and the mechanisms of endocrine factors, signaling pathways, miRNAs and protein acetylation regulating cell glycolysis, aiming to provide some important reference for the elucidation of the molecular metabolism of spermatogenesis and clinical treatment of relevant diseases.
作者
易晓东
张怡宁
肖帅
雷小灿
YI Xiao-dong;ZHANF Yi-ning;XIAO Shuai;LEI Xiao-can(Department of Histology and Embryology,School of Basic Medical Sciences,Zunyi Medical University,Zunyi,Guizhou 563003,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2019年第10期923-927,共5页
National Journal of Andrology
基金
国家自然科学基金(81860733)
贵州省科学技术基金项目(黔科合基础[2019]1344)
2018年国家级大学生创新创业训练计划项目(201810661015
ZYDC2018050)~~
关键词
支持细胞
糖代谢
精子发生
调控机制
Sertoli cell
glycometabolism
spermatogenesis
regulatory mechanism
