摘要
目的 评价麦粒灸结合西医常规疗法治疗血液透析继发甲状旁腺功能亢进的临床疗效.方法 将符合入选标准的 80 例血液透析继发甲状旁腺功能亢进患者按随机数字表法分为 2 组,每组 40例.对照组采用西药常规疗法治疗,观察组在对照组基础上结合麦粒灸治疗.2组均连续治疗3个月.采用比色法检测血清钙、磷、ALP水平,采用双抗体夹心ELISA法检测全段甲状旁腺激素(intactparathyroid hormone, iPTH),采用SF-36健康调查量表(MOS 36-Item Short Form Health Survey, SF-36)评估生存质量,评价临床疗效.结果 观察组总有效率为 95.0%(38/40)、对照组为 80.0%(32/40),2 组比较差异有统计学意义(χ^2=4.114,P=0.043).治疗后,观察组血清钙[(2.27±0.18)mmol/L比(2.07±0.16)mmol/L, t=5.252]水平高于对照组(P<0.01);血清磷[(1.32±0.02)mmol/L比(1.60±0.04)mmol/L,t=39.598]、iPTH[(210.15±16.24)pg/ml比(325.41±21.55)pg/ml,t=27.015]、ALP[(71.14±10.73)U/L比(116.42± 12.26)U/L,t=17.577]水平低于对照组(P<0.01).观察组治疗后躯体健康、躯体角色功能、躯体疼痛、总体健康评分、精力、社会功能、情绪角色功能、心理健康评分均高于对照组(t值分别为2.399、3.572、2.684、3.598、3.076、2.811、4.958、2.176,P值均<0.01).结论 麦粒灸联合西医常规疗法可纠正血液透析继发甲状旁腺功能亢进患者的钙磷代谢紊乱状态,降低甲状旁腺激素分泌水平,提高生存质量,且安全性较好.
Objective To explore the effect of grain-moxibustion combined with routine western medicine therapy on the quality of life of the patients with secondary hyperparathyroidism after hemodialysis. Methods According to the random number table, 80 hemodialysis patients with secondary hyperparathyroidismin were divided into two groups, 40 in each group. The control group was treated with routine western medicine therapy, while the observation group was treated with grain-moxibustionon the basis of the control group. Both groups were treated for 3 months. Clinical curative effect was evaluated after treatment. The quality of life was assessed by SF-36 Health Survey (SF-36) before and after treatment, serum Ca, P and ALP levels were measured by colorimetry, and intact parathyroid hormone (iPTH) was detected by double antibody sandwich ELISA. Results Total effective rate was 95.0% (38/40) in the observation group and 80.0% (32/40) in the control group, where there was significantly difference between two groups (χ2=4.114, P=0.043). After treatment, the levels of serum Ca (2.27 ± 0.18 mmol/L vs. 2.07 ± 0.16 mmol/L, t=5.252) in the observation group was significantly higher than that in the control group (P<0.01), the levels of serum P (1.32 ± 0.02 mmol/L vs. 1.60 ± 0.04 mmol/L, t=39.598), iPTH (210.15 ± 16.24 pg/ml vs. 325.41 ± 21.55 pg/ml, t=27.015) and ALP (71.14 ± 10.73 U/L vs. 116.42 ± 12.26 U/L, t=17.577) were significantly lower than those in the control group (P<0.01). After treatment, the scores of physical health, body role function, body pain, overall health score, middle energy, social function, emotional role function and mental health in the observation group were significantly higher than those in the control group (t=2.399, 3.572, 2.684, 3.598, 3.076, 2.811, 4.958, 2.176, P<0.01). Conclusions Grain-moxibustion combined with routine western medicine therapy in treatment of hemodialysis patients with secondary hyperparathyroidism can adjust the calcium and phosphate metabolic disorders, reduce the parathyroid hormone levels, and they improve the quality of life of patients.
作者
马红岩
蔡寸
Ma Hongyan;Cai Cun(Nephrology Department,Fangcun Hospital of Guangdong Traditional Chinese Medicine Hospital,Guangzhou 510000,China;Dialysis Department,University Town Hospital of Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 511400,China)
出处
《国际中医中药杂志》
2019年第10期1062-1066,共5页
International Journal of Traditional Chinese Medicine
关键词
甲状旁腺功能亢进症
继发性
麦粒灸疗法
血液透析滤过
生活质量
中西医结合疗法
Hyperparathyroidism,secondary
Moxibustion with seed sized moxa cone therapy
Hemodiafiltration
Quality of life
Integrated Chinese traditional and western medicine therapy
