摘要
目的了解运城市涂阳肺结核患者的耐药状况,为结核病的防治提供科学依据。方法对运城市各县(区)2016年8月-2017年8月期间培养为阳性的菌株送至运城市疾病预防控制中心结核病实验室进行菌种鉴定和药敏试验。结果运城市结核杆菌总耐药率26.10%,初治耐药率23.04%,复治耐药率49.02%,耐多药率5.54%,多耐药率4.39%,总的单耐药率16.17%;复治涂阳患者中男性耐药率(51.28%)与女性(23.81%)之间差异有统计学意义(χ^2=4.239,P<0.05);6种抗结核药物中,耐药率最高的利福平(R)(18.94%),其次为异烟肼(H)(9.47%),总体耐药顺位依次为利福平(R)(18.94%)、异烟肼(H)(9.47%)、链霉素(S)(8.78%)、氧氟沙星(OFX)(3.46%)、卡那霉素(Km)(1.39%)、乙胺丁醇(E)(0.92%)。结论山西运城地区结核分枝杆菌耐药情况不容乐观,尤其是耐多药发展趋势严峻,应加强耐药结核病防治工作,避免或减少耐药结核病的产生。
Objective To understand the drug resistant status of smear-positive pulmonary tuberculosis patients in Yuncheng,provide scientific basis for the prevention and treatment of tuberculosis.Methods The culture-positive strains from Aug.2016 and Aug.2017 in Yuncheng counties were sent to TB laboratory of Yuncheng center for disease control and prevention for strains identification and drug susceptibility testing.Results The total resistance rate of tuberculosis bacillus in Yuncheng was 26.10%,initial drug resistance rate and retreatment drug resistance rate was 23.04% and 49.02% respectively.Multidrug resistance rate was 5.54%,multi-drug resistance rate was 4.39% and single drug resistance rate was 16.17%.The male drug resistance rate(51.28%)was higher than that in female(23.81%) of retreatment of smear-positive pulmonary tuberculosis patients.There was statistically significant difference(χ^2=4.239,P<0.05).The highest rate of drug resistance was Rifampin(18.94%),the next was Isoniazid(9.47%).Drug resistance rates ranked from high to low as Rifampin(R)(18.94%),Isoniazid(H)(9.47%),Streptomycin(S)(8.78%),Ofloxacin(OFX)(3.46%),Kanamycin(Km)(1.39%)and Ethambutol(E)(0.92%).Conclusion The situation of drug resistant TB in Yuncheng is not optimistic,especially the development trend of multidrug resistance is severe.In the future,the prevention and control of drug-resistant tuberculosis should be strengthened to reduce the generation of drug-resistant TB.
作者
商亚丽
李清桃
徐青龙
SHANG Ya-li;LI Qing-tao;XU Qing-long(Shanxi Provincial Center for Disease Control and Prevention,Taiyuan,Shanxi 030012,China;Yuncheng Municipal Center for Disease Control and Prevention)
出处
《中国公共卫生管理》
2019年第5期706-709,共4页
Chinese Journal of Public Health Management
关键词
结核病
耐多药
耐药率
tuberculosis
multidrug resistant
drug resistance rate
