摘要
目的探究丙种球蛋白在新生儿ABO溶血中的治疗效果。方法选取2017年5月-2019年3月就诊于该院的ABO溶血患儿50例,采用随机数字表法分为观察组与对照组,各25例。对照组给予蓝光照射治疗,观察组在蓝光照射基础上给予静脉注射免疫球蛋白治疗。对比两组治疗情况、血清指标水平变化及不良反应发生情况。结果观察组患儿黄疸消退时间为(3.45±1.36)d、蓝光照射时间(57.43±12.26)h、住院时间(6.05±1.33)d,均短于对照组(7.32±1.28)d、(68.93±13.34)h、(8.79±2.14)d,差异有统计学意义(t=10.361、3.174、5.437,P=0.000、0.003、0.000);观察组治疗后Hb水平为(147.36±22.21)g/L高于对照组(132.52±20.45)g/L,TBil水平为(209.37±46.52)mol/L、RC水平为(0.024±0.005)mmol/L均低于对照组(240.97±50.64)mol/L、RC水平为(0.045±0.005),差异有统计学意义(t=2.623、2.298、14.849,P=0.012、0.026、0.000 <0.05);两组不良反发生率比较,差异无统计学意义(χ^2=1.705,P=0.082>0.05)。结论新生儿ABO溶血采用丙种球蛋白联合光照治疗可取得较好的治疗效果,利于缩短黄疸持续时间,改善患儿临床症状及血清相关指标水平,治疗安全性较高。
Objective To investigate the therapeutic effect of gamma globulin in neonatal ABO hemolysis. Methods A total of 50 ABO hemolyzed children who were admitted to our hospital from May 2017 to May 2019 were randomly divided into observation group and control group, 25 cases each. The control group was treated with blue light irradiation,and the observation group was given intravenous immunoglobulin therapy on the basis of blue light irradiation. The treatment status, changes in serum levels and adverse reactions were compared between the two groups. Results In the observation group, the jaundice regression time was(3.45±1.36) d, blue light irradiation time(57.43±12.26) h, hospitalization time(6.05±1.33) d, which were shorter than the control group(7.32±1.28) d,(68.93± 13.34)h,(8.79±2.14)d, the difference was statistically significant(t=10.361, 3.174, 5.437, P=0.000, 0.003, 0.000);the Hb level of the observation group was(147.36±22.21) g/L after treatment. In the control group(132.52±20.45) g/L, the TBil level was(209.37±46.52) mmol/L, and the RC level was(0.024±0.005), which was lower than the control group(240.97±50.64) mmol/L,and the RC level was(0.045±0.005)mmol/L, the difference was statistically significant(t=2.623,2.298, 14.849, P=0.012,0.026, 0.000<0.05);there was no significant difference in the adverse reaction rate between the two group,the difference was statistically significants(χ^2=1.705, P=0.082 >0.05). Conclusion Neonatal ABO hemolysis can achieve better therapeutic effect by using gamma globulin combined with light therapy, which can shorten the duration of jaundice,improve the clinical symptoms and serum related indicators of children, and have higher treatment safety.
作者
林成梅
LIN Cheng-mei(Department of Pediatrics,Xuyi People's Hospital,Huai'an,Jiangsu Province,211700 China)
出处
《系统医学》
2019年第19期83-85,共3页
Systems Medicine
关键词
新生儿溶血
丙种球蛋白
蓝光照射
血清指标
不良反应
Neonatal hemolysis
Gamma globulin
Blue light irradiation
Serum index
Adverse reactions
