摘要
目的探讨阿奇霉素联合阴道栓剂治疗非淋菌性宫颈炎的效果。方法选择2016年5月至2018年11月收治的78例非淋菌性宫颈炎患者作为研究对象,以随机数字表法将其分为对照组和观察组,各39例。对照组给予阿奇霉素治疗,观察组在对照组基础上联合阴道栓剂治疗。比较两组阴道排液时间、宫颈修复时间、不良反应发生情况、治疗前、后血清炎性因子及免疫球蛋白水平。结果观察组患者阴道排液时间和宫颈修复时间均显著短于对照组(P<0.05)。观察组的不良反应总发生率为7.69%,低于对照组的30.77%(P<0.05)。所有不良反应均在停药后自行缓解消退。治疗后,两组患者血清IL-4、PGE2和TNF-α水平均较治疗前明显降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者IgA、IgG和IgM水平均较治疗前升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论阿奇霉素联合阴道栓剂治疗非淋菌性宫颈炎的效果显著,可有效改善患者的临床症状,减轻炎性反应,提高免疫功能。
Objective To investigate the effect of azithromycin combined with vaginal suppository in the treatment of non-gonococcal cervicitis. Methods Seventy-eight cases of non-gonococcal cervicitis from May 2016 to November 2018 were selected as the study objects and divided into control group and observation group, with 39 cases in each group. The control group was treated with azithromycin, and the observation group was treated with vaginal suppository on the basis of the control group. The time of vaginal drainage and cervical repair, adverse reactions, the levels of serum inflammatory factors and immunoglobulin before and after treatment were compared between the two groups. Results The time of vaginal drainage and cervical repair in the observation group were significantly shorter than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 7.69%, which was lower than 30.77% in the control group(P<0.05). All the adverse reactions relieved and subsided after the drug were stopped. After treatment, the levels of serum IL-4, PGE2 and TNF-α in the two groups were significantly lower than those before treatment, and those in the observation group were lower than the control group, and the differences were statistically significant(P <0.05). After treatment, the levels of IgA, IgG and IgM in the two groups were higher than those before treatment, and those in the observation group were higher than the control group, and the differences were statistically significant(P<0.05). Conclusion Azithromycin combined with vaginal suppository in the treatment of non-gonococcal cervicitis has a significant effect,which can effectively improve the clinical symptoms of patients, reduce the inflammatory response, and enhance the immune function.
作者
王亚茹
邵娟
WANG Ya-ru;SHAO Juan(Xi'an Maternal and Child Health Hospital,Xi'an 710002;Xi'an No.5 Hospital,Xi'an 710082,China)
出处
《临床医学研究与实践》
2019年第32期92-94,共3页
Clinical Research and Practice
关键词
阿奇霉素
阴道栓剂
非淋菌性阴道炎
炎性因子
免疫球蛋白
不良反应
azithromycin
vaginal suppository
non-gonococcal vaginitis
inflammatory factors
immunoglobulin
adverse reactions
