摘要
为了解误吸含铀化合物气溶胶后放射性铀在体内的分布滞留情况,本研究基于国际放射防护委员会(International Commission on Radiological Protection,ICRP)130号报告给出的生物动力学模型,使用MATLAB软件中Simulink仿真工具建立人呼吸道隔室沉积及廓清仿真模型,并进行模拟计算。结果显示:含铀化合物的体内滞留廓清情况主要与吸入化合物的溶解度相关,溶解度高的化合物如UF6,数天后即从肺中彻底廓清,而难溶性化合物如UO2,将在肺中滞留20余年。本模型能准确反映铀在体内的滞留分布状况,可用于吸入性内污染发生后放射性铀肺部滞留量计算以及制定后续医疗救助方案。
[Background]In the production process of nuclear industry,excessive intake of aerosols uraniumcontaining compounds due to accidents or other circumstances occurs from time to time.[Purpose]This study aims to investigate the deposition and transfer of internal contamination caused by inhalation of radioactive uranium aerosols.[Methods]The latest respiratory tract model based on the Simulink simulation tool in MATLAB software was established according to the 130th report published by the ICRP(International Commission on Radiological Protection).Distribution and retention of uranium aerosols in the lung were simulated by combining with the specific biological metabolism and physical characteristics of several uranium containing compounds,so as to evaluate and predict the health hazard of internal pollution to patients.[Results]Simulation results show that 55.37%of single inhalation of UF6 entered the gastrointestinal tract and 12.89%was absorbed by blood and discharged from the lungs within the next few days.After inhalation of ADU,UO3 and UF4,these compounds stay in the lungs for a long time,and it takes about 300~1000 days to clear from the lungs.Insoluble compounds such as UO2 and U3O8 will remain in the lung for more than 20 years.[Conclusions]The distribution and retention of different uranium compounds in vivo are different,and the treatment method needs to be selected according to the actual situation.
作者
袁炜烨
王一迪
席悦
孙亮
涂彧
YUAN Weiye;WANG Yidi;XI Yue;SUN Liang;TU Yu(State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection and Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China)
出处
《核技术》
CAS
CSCD
北大核心
2019年第11期43-50,共8页
Nuclear Techniques
基金
国家自然科学基金(No.11575124)
核能开发项目(No.[2016]1295)资助~~
